TRIP4 and ASCC2

Number of citations of the paper that reports this interaction (PubMedID 12077347)
29

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TRIP4	ASCC2
Description		thyroid hormone receptor interactor 4	activating signal cointegrator 1 complex subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Body Neuromuscular Junction Protein-containing Complex RQC-trigger Complex	Nucleus Nucleoplasm Nuclear Speck Cytosolic Ribosome RQC-trigger Complex DNA Repair Complex
	Molecular Function	Protease Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Histone Acetyltransferase Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding	Protein Binding Ubiquitin Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Estrogen Receptor Signaling Pathway Ribosome Disassembly Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	DNA Replication DNA Repair DNA Alkylation Repair Regulation Of DNA-templated Transcription DNA Damage Response Ribosome Disassembly Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	ALKBH3 mediated reversal of alkylation damage ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 24162737) Neuroticism ( 29255261)	Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Crohn's disease ( 28067908) Hemoglobin levels ( 32327693) IgA levels ( 28628107) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278) Spleen volume ( 34128465) Telomere length ( 24478790) Tonsillectomy ( 27941131) Type 2 diabetes ( 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		23 interacting genes: AR ASCC2 ASCC3 CREBBP EP300 ESR1 ESR2 GTF2A1 JUN NCOA1 NEK6 NFKB1 NR2F2 PAX9 PPARG RARA RELA RXRA SRF TBP THRB UBC XBP1	41 interacting genes: ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT KATNAL1 KDM1A LPL MAP3K1 MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 PRPF18 RADIL RNF11 RPA1 RPLP1 SASH1 SMURF1 SNRPB SNW1 TBC1D17 TRIP4 UBC URM1
Entrez ID		9325	84164
HPRD ID		05140	16515
Ensembl ID		ENSG00000103671	ENSG00000100325
Uniprot IDs		Q15650	Q9H1I8
PDB IDs		2E5O 8ALZ 8YEW 8YEY 8YFI 8YFJ 8YXW 8YXX	2DI0 6YXQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm Transcription Coactivator Binding Nuclear Receptor Activity Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Hormone-mediated Signaling Pathway Regulation Of MiRNA Metabolic Process Chromatin Binding DNA-binding Transcription Factor Activity Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Nuclear Receptor-mediated Signaling Pathway DNA Binding Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hormone Regulation Of MiRNA Transcription Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Transcription Regulator Complex Chromatin DNA Binding Transcription Cis-regulatory Region Binding MRNA Transcription By RNA Polymerase II Enzyme Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific MRNA Transcription Positive Regulation Of Metabolic Process RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process	Macromolecule Metabolic Process Nucleoplasm
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