IL32 and IFT140

		IL32	IFT140
Description		interleukin 32	intraflagellar transport 140
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Membrane	Nucleoplasm Cytoplasm Mitochondrion Centrosome Centriole Cytoskeleton Cilium Axoneme Intraciliary Transport Particle A Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Ciliary Tip Non-motile Cilium Cone Photoreceptor Outer Segment
	Molecular Function	Cytokine Activity Protein Binding	Protein Binding
	Biological Process	Defense Response Immune Response Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Type III Interferon Production Negative Regulation Of Viral Life Cycle	Determination Of Left/right Symmetry Heart Development Regulation Of Smoothened Signaling Pathway Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Limb Morphogenesis Intraciliary Retrograde Transport Photoreceptor Cell Outer Segment Organization Intraciliary Transport Embryonic Digit Morphogenesis Embryonic Cranial Skeleton Morphogenesis Cilium Assembly Protein Localization To Cilium Regulation Of Cilium Assembly Non-motile Cilium Assembly Embryonic Brain Development
Pathways		Other interleukin signaling RAC3 GTPase cycle	Hedgehog 'off' state Intraflagellar transport
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) HIV-1 susceptibility ( 22174851) Liver enzyme levels (alanine transaminase) ( 33972514)	Coronary artery disease ( 29212778 33020668) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
Interacting Genes		12 interacting genes: C1QB HSPA8 IFT140 KPNA5 NDN NQO2 PRTN3 RHBDD2 RPL4 SNRNP70 TUT1 ZFPM2	12 interacting genes: CELSR3 CRK DNAJA3 IL32 NEK2 NHERF2 PFDN1 RAB11FIP3 RANBP2 TELO2 TRAP1 ZNF263
Entrez ID		9235	9742
HPRD ID		09346	11093
Ensembl ID		ENSG00000008517	ENSG00000187535
Uniprot IDs		C6GKH1 G3LU47 P24001	Q96RY7
PDB IDs			8BBF 8BBG 8FGW 8FH3
Enriched GO Terms of Interacting Partners?			Protein Folding Negative Regulation Of Innate Immune Response Protein Localization To Membrane Unfolded Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity Negative Regulation Of Immune Response Localization Within Membrane Helper T Cell Diapedesis Cerebellar Neuron Development Protein Phosphorylated Amino Acid Binding Negative Regulation Of Defense Response Neuromuscular Junction Response To Cholecystokinin Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Negative Regulation Of Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Intercellular Bridge Cytoplasmic Periphery Of The Nuclear Pore Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Type III Interferon Production Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cleavage Furrow 'de Novo' Cotranslational Protein Folding TTT Hsp90 Cochaperone Complex Translational Attenuation
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