BMP15 and GDF9

Number of citations of the paper that reports this interaction (PubMedID 12446716)
0

Data Source:
HPRD (in vitro)

		BMP15	GDF9
Description		bone morphogenetic protein 15	growth differentiation factor 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity	Cytokine Activity Growth Factor Activity
	Biological Process	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Female Gamete Generation	Oocyte Growth Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Regulation Of Progesterone Secretion
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS			Asthma ( 31619474)
Interacting Genes		3 interacting genes: BMPR1B GDF9 KDM6A	46 interacting genes: ACVR2A ADPGK ANXA7 APLP1 BMP15 BMPR1A BMPR1B BMPR2 BTBD2 CDKN1A CDKN2C CRELD1 CRIPTO DLEU1 DNM2 FOXG1 FXYD6 GADD45G HSPA9 ILF3 KDM1A KIF22 LSM3 MOB4 MPHOSPH6 MYCBP NDUFB9 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PMF1 PRKRA PSMD11 RAB27A RSRC1 S100A8 SAT1 SERPINB9 SMN1 SNRPG STRN4 TK1 TRIB3 WASHC3
Entrez ID		9210	2661
HPRD ID		02216	03560
Ensembl ID		ENSG00000130385	ENSG00000164404
Uniprot IDs		O95972	B4DXG3 O60383
PDB IDs
Enriched GO Terms of Interacting Partners?		HFE-transferrin Receptor Complex Developmental Growth Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Chondrocyte Proliferation BMP Receptor Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Ovarian Cumulus Expansion Endochondral Bone Morphogenesis Regulation Of Female Gonad Development Regulation Of Progesterone Secretion Oocyte Growth Histone H3K27me2/H3K27me3 Demethylase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors MLL3/4 Complex Cartilage Condensation Positive Regulation Of Chondrocyte Differentiation BMP Binding Retinal Ganglion Cell Axon Guidance Ovulation Cycle Histone Demethylase Activity Cell Aggregation Enzyme-linked Receptor Protein Signaling Pathway Chondrocyte Development Histone Methyltransferase Complex Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Bone Morphogenesis Ovulation Cycle Process Positive Regulation Of Bone Mineralization Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Biomineral Tissue Development SMAD Binding Regulation Of Chondrocyte Differentiation Positive Regulation Of Ossification	BMP Receptor Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Cellular Response To BMP Stimulus Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II BMP Binding Positive Regulation Of Osteoblast Differentiation Tricuspid Valve Morphogenesis Activin Receptor Signaling Pathway Regulation Of Bone Mineralization BMP Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Negative Regulation Of Chondrocyte Proliferation Regionalization Endochondral Bone Morphogenesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Developmental Process Positive Regulation Of SMAD Protein Signal Transduction HFE-transferrin Receptor Complex Mitral Valve Morphogenesis RNA Splicing, Via Transesterification Reactions Regulation Of Ossification Pharyngeal Arch Artery Morphogenesis Osteoblast Differentiation Mesenchyme Development Endocardial Cushion Development Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Programmed Cell Death Pattern Specification Process Regulation Of Osteoblast Differentiation Dorsal/ventral Pattern Formation Cellular Response To Growth Factor Stimulus Regulation Of SMAD Protein Signal Transduction Cellular Developmental Process Cell Differentiation SMN-Sm Protein Complex FAR/SIN/STRIPAK Complex Anterior/posterior Pattern Specification Kinase Activity Precatalytic Spliceosome Atrioventricular Valve Morphogenesis Epithelial Cell Proliferation Protein Binding
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