BMP15

Description		bone morphogenetic protein 15
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity
	Biological Process	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Female Gamete Generation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS
Novel Interacting Genes		3 novel interacting genes: BMPR1B GDF9 KDM6A
Interacting Genes		3 interacting genes: BMPR1B GDF9 KDM6A
Entrez ID		9210
HPRD ID		02216
Ensembl ID		ENSG00000130385
Uniprot IDs		O95972
PDB IDs
Enriched GO Terms of Interacting Partners?		HFE-transferrin Receptor Complex Developmental Growth Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Chondrocyte Proliferation BMP Receptor Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Ovarian Cumulus Expansion Endochondral Bone Morphogenesis Regulation Of Female Gonad Development Regulation Of Progesterone Secretion Oocyte Growth Histone H3K27me2/H3K27me3 Demethylase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors MLL3/4 Complex Cartilage Condensation Positive Regulation Of Chondrocyte Differentiation BMP Binding Retinal Ganglion Cell Axon Guidance Ovulation Cycle Histone Demethylase Activity Cell Aggregation Enzyme-linked Receptor Protein Signaling Pathway Chondrocyte Development Histone Methyltransferase Complex Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Bone Morphogenesis Ovulation Cycle Process Positive Regulation Of Bone Mineralization Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Biomineral Tissue Development SMAD Binding Regulation Of Chondrocyte Differentiation Positive Regulation Of Ossification
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