SCAF11 and SHMT2

		SCAF11	SHMT2
Description		SR-related CTD associated factor 11	serine hydroxymethyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Body	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Microtubule Cytoskeleton Membrane Mitochondrial Nucleoid Intracellular Organelle Lumen Extracellular Exosome BRISC Complex
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Chromatin Binding Glycine Hydroxymethyltransferase Activity Protein Binding L-allo-threonine Aldolase Activity Amino Acid Binding Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing	Regulation Of Oxidative Phosphorylation Regulation Of Translation Glycine Metabolic Process Glycine Biosynthetic Process L-serine Metabolic Process L-serine Biosynthetic Process One-carbon Metabolic Process Positive Regulation Of Cell Population Proliferation Formate Biosynthetic Process Glycine Biosynthetic Process From Serine Response To Type I Interferon Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Protein Tetramerization Protein Homotetramerization Regulation Of Mitochondrial Translation Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration
Pathways			Metabolism of folate and pterines RHOG GTPase cycle Mitochondrial protein degradation
Drugs			Pyridoxal phosphate Tetrahydrofolic acid Glycine Artenimol
Diseases
GWAS		Coronary artery disease ( 29212778) Fish- and plant-related diet ( 32066663) Hemoglobin levels ( 32327693) Morning person ( 30696823) Multiple sclerosis ( 31604244) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061 29483656)
Interacting Genes		14 interacting genes: ATXN1L PSEN1 RNF10 SHMT2 SNRNP70 SRPK1 SRSF1 SRSF2 SRSF3 SRSF4 STAT3 SUMO2 TUBA1C U2AF2	24 interacting genes: ACVR1B APP ARL6IP1 BRCC3 CAB39 CFTR CLEC2D CMTM5 COMMD6 CREB3 CSNK2B DUX4 ESR1 KASH5 KMT2D MAL2 NDRG1 NKD2 OGT PPARD PRKAG1 RND1 SCAF11 TUBA1C
Entrez ID		9169	6472
HPRD ID		04720	00717
Ensembl ID		ENSG00000139218	ENSG00000182199
Uniprot IDs		F8VXG7 Q99590	B4DJQ3 B4DLV4 P34897 Q5BJF5 V9HW06
PDB IDs			4PVF 5V7I 5X3V 6DK3 6H3C 6M5O 6QVG 6QVL 6R8F 7BYI 8AQL 8FJT 8FJU 8GKS 8GKT 8GKU 8GKW 8GKY 8GKZ 8QI7 8SSJ 8T4O 8T4P 8TLC 9BOX
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process RNA Splicing MRNA Metabolic Process Nuclear Speck MRNA Processing RNA Binding Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Nucleus MRNA Binding RNA Processing Nucleic Acid Binding Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of RNA Splicing Postsynapse To Nucleus Signaling Pathway Regulation Of Metabolic Process Nucleoplasm Cellular Response To Interleukin-17 RNA Splicing, Via Transesterification Reactions Primary MiRNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Response To Cytokine Sequence-specific MRNA Binding Response To Peptide Negative Regulation Of MRNA Metabolic Process U2-type Prespliceosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Catabolic Process Negative Regulation Of RNA Splicing Cellular Response To Cytokine Stimulus Negative Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Positive Regulation Of ATP Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process	Negative Regulation Of MiRNA Transcription Signal Transduction Release From Viral Latency Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of MiRNA Transcription Neuron Remodeling Regulation Of Purine Nucleotide Metabolic Process Protein Kinase Regulator Activity Regulation Of MiRNA Metabolic Process Peptidyl-threonine Phosphorylation Serine/threonine Protein Kinase Complex Intracellular Signal Transduction Protein Serine/threonine Kinase Binding Positive Regulation Of Monocyte Chemotaxis Nuclear Steroid Receptor Activity Protein-containing Complex Regulation Of Activin Receptor Signaling Pathway Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of Cell Population Proliferation Amylin Binding Neuron Maturation Cell Maturation Positive Regulation Of Toll Signaling Pathway Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Protein-containing Complex Assembly Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Monocyte Chemotaxis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus 14-3-3 Protein Binding Developmental Process Involved In Reproduction Cellular Response To Stress Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Myoblast Differentiation NF-kappaB Binding Linoleic Acid Binding Beta-catenin-TCF Complex Assembly
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