CBFA2T2 and PDP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CBFA2T2	PDP1
Description		CBFA2/RUNX1 partner transcriptional co-repressor 2	pyruvate dehydrogenase phosphatase catalytic subunit 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (acetyl-transferring)]-phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Epithelial Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Intestinal Epithelial Cell Differentiation	Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Peptidyl-threonine Dephosphorylation
Pathways		Specification of primordial germ cells	Regulation of pyruvate dehydrogenase (PDH) complex
Drugs
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Triglyceride levels ( 32203549)
Interacting Genes		34 interacting genes: APP ATN1 ATXN1L BAG4 CBFA2T3 CBFB CEP83 FBXL19 GTF2E1 ID3 KIFC3 KRTAP13-2 LBP MAGEA6 MDFI NCOR1 NCOR2 NEUROG1 NOTCH3 NTAQ1 PDP1 PEX14 PHAF1 PRDM6 RERE RUNX1 SIKE1 SIN3A SORBS3 TAL2 TCF4 TCP1 ZC2HC1A ZNF652	12 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 INCA1 KRTAP6-2 MEOX2 OGT PDHA1 PLEKHF2 PRKCD SIRT3
Entrez ID		9139	54704
HPRD ID		04721	16185
Ensembl ID		ENSG00000078699	ENSG00000164951
Uniprot IDs		O43439	Q6P1N1 Q9P0J1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Core-binding Factor Complex Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Transcription Regulator Inhibitor Activity Nucleus Histone Deacetylase Complex Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Protein Binding Transcription Repressor Complex Chromatin Binding Protein Dimerization Activity Regulation Of ATP Metabolic Process DNA Binding Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Regulation Of Purine Nucleotide Metabolic Process Response To Catecholamine Neuron Differentiation Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of Glycolytic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of ATP Metabolic Process Amyloid-beta Complex	Positive Regulation Of Ceramide Biosynthetic Process Acetyl-CoA Biosynthetic Process Regulation Of Phosphorus Metabolic Process Salivary Gland Morphogenesis Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Positive Regulation Of Lipid Biosynthetic Process Protein Tyrosine Kinase Activator Activity Protein Tyrosine Kinase Activity Regulation Of Membrane Lipid Metabolic Process Positive Regulation Of Lipid Metabolic Process Enzyme Binding Acetyl-CoA Metabolic Process Gland Morphogenesis Positive Regulation Of Amide Metabolic Process Regulation Of Lipid Biosynthetic Process Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Metanephric Proximal Convoluted Tubule Development Epithelium Development Propionyl-CoA Biosynthetic Process Transferase Activity C-acetyltransferase Activity Positive Regulation Of Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Signaling Multivesicular Body, Internal Vesicle Lumen Regulation Of Catalytic Activity Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Regulation Of Protein Modification Process Regulation Of MAPK Cascade Positive Regulation Of DNA Metabolic Process Tissue Development Kidney Epithelium Development Positive Regulation Of Phosphate Metabolic Process Shc-EGFR Complex Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Catalytic Activity Regulation Of Lateral Mesodermal Cell Fate Specification Regulation Of Lipid Metabolic Process Regulation Of Amide Metabolic Process Positive Regulation Of Sphingomyelin Catabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?