CBFA2T2 and NEUROG1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		CBFA2T2	NEUROG1
Description		CBFA2/RUNX1 partner transcriptional co-repressor 2	neurogenin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromatin Nucleus Neuronal Cell Body Perikaryon
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Epithelial Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Intestinal Epithelial Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Thorax And Anterior Abdomen Determination Nervous System Development Sensory Organ Development Exit From Mitosis Trigeminal Nerve Development Vestibulocochlear Nerve Formation Neurogenesis Cell Differentiation Neuron Differentiation Peristalsis Forebrain Development Auditory Behavior Positive Regulation Of Exit From Mitosis Genitalia Morphogenesis Inner Ear Morphogenesis Cell Fate Commitment Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Organ Development Genitalia Development Inner Ear Development Neuromuscular Process Controlling Balance Positive Regulation Of DNA-binding Transcription Factor Activity Axon Development Mastication Cochlea Development Cochlea Morphogenesis Craniofacial Suture Morphogenesis Learned Vocalization Behavior Negative Regulation Of Relaxation Of Muscle Negative Regulation Of Saliva Secretion Hard Palate Morphogenesis
Pathways		Specification of primordial germ cells
Drugs
Diseases
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Triglyceride levels ( 32203549)
Interacting Genes		34 interacting genes: APP ATN1 ATXN1L BAG4 CBFA2T3 CBFB CEP83 FBXL19 GTF2E1 ID3 KIFC3 KRTAP13-2 LBP MAGEA6 MDFI NCOR1 NCOR2 NEUROG1 NOTCH3 NTAQ1 PDP1 PEX14 PHAF1 PRDM6 RERE RUNX1 SIKE1 SIN3A SORBS3 TAL2 TCF4 TCP1 ZC2HC1A ZNF652	8 interacting genes: CBFA2T2 CREBBP MPHOSPH10 RUNX1T1 SMAD1 TARBP2 TCF12 TCF4
Entrez ID		9139	4762
HPRD ID		04721	03430
Ensembl ID		ENSG00000078699	ENSG00000181965
Uniprot IDs		O43439	F1T0H3 Q92886
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Core-binding Factor Complex Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Transcription Regulator Inhibitor Activity Nucleus Histone Deacetylase Complex Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Protein Binding Transcription Repressor Complex Chromatin Binding Protein Dimerization Activity Regulation Of ATP Metabolic Process DNA Binding Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Regulation Of Purine Nucleotide Metabolic Process Response To Catecholamine Neuron Differentiation Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of Glycolytic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of ATP Metabolic Process Amyloid-beta Complex	Transcription Regulator Complex Transcription Corepressor Activity DNA-binding Transcription Factor Binding MiRNA Processing Nucleoplasm Regulation Of Cell Differentiation E-box Binding DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Nucleic Acid Metabolic Process Nucleus Histone H3K27 Acetyltransferase Activity Chromatin Homomeric SMAD Protein Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Cell Differentiation Regulation Of SiRNA Processing Positive Regulation Of Neuron Differentiation Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Global Gene Silencing By MRNA Cleavage Beta-catenin-TCF7L2 Complex Mpp10 Complex Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Developmental Process Negative Regulation Of Defense Response To Virus By Host TFIIB-class Transcription Factor Binding RNA Metabolic Process Regulation Of Developmental Process MRF Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Cell Differentiation Positive Regulation Of Neuron Projection Development Anti-Mullerian Hormone Receptor Signaling Pathway Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Protein Dimerization Activity
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