AIP and PDE4A

Number of citations of the paper that reports this interaction (PubMedID 12810716)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		AIP	PDE4A
Description		AHR interacting HSP90 co-chaperone	phosphodiesterase 4A
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Aryl Hydrocarbon Receptor Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Aryl Hydrocarbon Receptor Binding GAF Domain Binding Unfolded Protein Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity CAMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Protein Targeting To Mitochondrion Xenobiotic Metabolic Process Positive Regulation Of DNA-templated Transcription Protein Maturation	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Cellular Response To Xenobiotic Stimulus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Aryl hydrocarbon receptor signalling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	DARPP-32 events G alpha (s) signalling events
Drugs			Caffeine Theophylline Dyphylline Enprofylline Dipyridamole Iloprost Oxtriphylline Amrinone Roflumilast Piclamilast Rolipram Crisaborole Ibudilast Propentofylline Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam Trapidil
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Urate levels ( 31578528)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 31604244) Plateletcrit ( 32888494)
Interacting Genes		22 interacting genes: AHR ARNT BTG3 CEBPA CLEC7A CSNK2A1 EGFR ERBB2 GNA13 GNAQ HSP90AA1 HTR6 HUNK IKBKG IRF7 LCOR PDE4A PPARA PTGES3 STIP1 TNNI3K TOMM20	7 interacting genes: AIP CYB561D2 LYN OSGIN1 PFKFB1 PIAS4 SMARCA4
Entrez ID		9049	5141
HPRD ID		10408	02527
Ensembl ID		ENSG00000110711	ENSG00000065989
Uniprot IDs		A0A804HJ38 A0A804HKL7 O00170	P27815
PDB IDs		2LKN 4AIF 4APO 7ZUB 8QMO	2QYK 3I8V 3TVX
Enriched GO Terms of Interacting Partners?		Hsp90 Protein Binding Nuclear Aryl Hydrocarbon Receptor Complex Signal Transduction Intracellular Signal Transduction Embryonic Placenta Development Protein Folding Chaperone Complex Telomerase Holoenzyme Complex Assembly Protein-containing Complex Nuclear Receptor Activity Aryl Hydrocarbon Receptor Complex Intestinal Epithelial Structure Maintenance ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Defense Response Positive Regulation Of Catabolic Process Protein Heterodimerization Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Guanyl Nucleotide Binding Protein Stabilization Ruffle Membrane Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Kinase Activity G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding ERBB2 Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Unfolded Protein Binding Regulation Of Multicellular Organismal Process Maintenance Of Gastrointestinal Epithelium Protein Import Into Mitochondrial Matrix Response To Xenobiotic Stimulus Regulation Of Intracellular Signal Transduction RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation	Platelet Degranulation Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Postsynaptic Specialization, Intracellular Component Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Dendritic Cell Apoptotic Process Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Positive Regulation Of Double-strand Break Repair Negative Regulation Of Cell Growth Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Nucleosome Array Spacer Activity Nuclear Matrix Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Glucose Mediated Signaling Pathway Transcription Coregulator Activity GAF Domain Binding Transmembrane Ascorbate Ferrireductase Activity Ascorbate Homeostasis Transmembrane Monodehydroascorbate Reductase Activity Limb Epidermis Development Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Interleukin-5-mediated Signaling Pathway Negative Regulation Of Protein Localization To Chromatin Phosphatidylinositol 3-kinase Activator Activity C-X-C Chemokine Receptor CXCR4 Signaling Pathway Histamine Secretion Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Histamine Transport Mitochondrial Crista Regulation Of Mast Cell Proliferation Signaling Receptor Activator Activity Transcription Corepressor Activity Negative Regulation Of Growth Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
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