PDE4A and PIAS4

Number of citations of the paper that reports this interaction (PubMedID 20196770)
0

Data Source:
BioGRID (enzymatic study)

		PDE4A	PIAS4
Description		phosphodiesterase 4A	protein inhibitor of activated STAT 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Transferase Complex
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity CAMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity SUMO Ligase Activity
	Biological Process	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Cellular Response To Xenobiotic Stimulus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response Central Nervous System Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Sumoylation Positive Regulation Of Protein Sumoylation Vitamin D Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of MRNA Stability Negative Regulation Of DNA-templated Transcription Limb Epidermis Development MRNA Destabilization Regulation Of Cellular Response To Stress Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		DARPP-32 events G alpha (s) signalling events	Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs		Caffeine Theophylline Dyphylline Enprofylline Dipyridamole Iloprost Oxtriphylline Amrinone Roflumilast Piclamilast Rolipram Crisaborole Ibudilast Propentofylline Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam Trapidil
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 31604244) Plateletcrit ( 32888494)	Chronic lymphocytic leukemia ( 28165464) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: AIP CYB561D2 LYN OSGIN1 PFKFB1 PIAS4 SMARCA4	91 interacting genes: ACTN1 ALDOA AR AREL1 BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G GATA1 HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KNTC1 KPNB1 KRT18 LAMP2 LCE1D LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRKCZ PRPF40A PTN RBBP8 RIF1 RPA2 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNAI2 SNIP1 STIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TOP1 TOP2A TP53 TRIM27 TRIM32 TRIM38 UBE2I UBE2K VHL VIM YY1 ZBTB34 ZHX1 ZNF512B ZW10
Entrez ID		5141	51588
HPRD ID		02527	06910
Ensembl ID		ENSG00000065989	ENSG00000105229
Uniprot IDs		P27815	B3KMR4 Q8N2W9
PDB IDs		2QYK 3I8V 3TVX
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Postsynaptic Specialization, Intracellular Component Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Dendritic Cell Apoptotic Process Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Positive Regulation Of Double-strand Break Repair Negative Regulation Of Cell Growth Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Nucleosome Array Spacer Activity Nuclear Matrix Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Glucose Mediated Signaling Pathway Transcription Coregulator Activity GAF Domain Binding Transmembrane Ascorbate Ferrireductase Activity Ascorbate Homeostasis Transmembrane Monodehydroascorbate Reductase Activity Limb Epidermis Development Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Interleukin-5-mediated Signaling Pathway Negative Regulation Of Protein Localization To Chromatin Phosphatidylinositol 3-kinase Activator Activity C-X-C Chemokine Receptor CXCR4 Signaling Pathway Histamine Secretion Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Histamine Transport Mitochondrial Crista Regulation Of Mast Cell Proliferation Signaling Receptor Activator Activity Transcription Corepressor Activity Negative Regulation Of Growth Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process SMAD Protein Signal Transduction Chromatin Binding Positive Regulation Of Cell Differentiation DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Heteromeric SMAD Protein Complex Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Ubiquitin Protein Ligase Binding Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Developmental Process
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