BMF and DYNLL2

Number of citations of the paper that reports this interaction (PubMedID 14561217)
40

Data Source:
HPRD (in vitro, in vivo)

		BMF	DYNLL2
Description		Bcl2 modifying factor	dynein light chain LC8-type 2
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Cytosol Plasma Membrane Myosin Complex	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Scaffold Protein Binding
	Biological Process	Apoptotic Process Negative Regulation Of Autophagy Positive Regulation Of Protein-containing Complex Assembly Cellular Response To UV Positive Regulation Of Apoptotic Process Anoikis Positive Regulation Of Release Of Cytochrome C From Mitochondria	Microtubule-based Process
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria	Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 24292274 26956414 28165464) Dehydroepiandrosterone sulphate levels ( 21533175) Endometrial cancer ( 27135401 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Ewing sarcoma ( 22327514) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Triglyceride levels ( 32203549)	Blood protein levels ( 30072576)
Interacting Genes		26 interacting genes: AQP1 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BCL2L2-PABPN1 CTAG1A CTAG1B CXCL9 DYNLL1 DYNLL2 GPSM3 LCN2 MAPK8 MCL1 MGAT5B MYO5A NNMT RECK REL SEC14L4 SHC3 TCF12 TFIP11 TRIM54	38 interacting genes: BMF C14orf119 C17orf67 CHMP5 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 F13A1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HOMER3 HSF5 IHO1 KIF2B MEOX2 MORN3 MSI2 MYO5A OTUD6A PAK1 PKIA PKIG PRKD3 RASGRP3 REDIC1 SKAP1 SMCP SPAG8 STXBP4 THAP10 TPPP XIAP ZAR1
Entrez ID		90427	140735
HPRD ID		05881	06489
Ensembl ID		ENSG00000104081	ENSG00000264364
Uniprot IDs		Q96LC9	Q96FJ2
PDB IDs		7CNU 8IQK 8IQL 8IQM 8R58	2XQQ 3P8M 4D07 7CNU
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage BH3 Domain Binding Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Mitochondrial Outer Membrane Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Damage Response Mitochondrion Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Anoikis Negative Regulation Of Programmed Cell Death Dendritic Cell Apoptotic Process Cellular Response To Stress Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Microtubule Associated Complex Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Stress Programmed Cell Death Cell Death Cell Surface Receptor Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Response To Reactive Oxygen Species Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Mitochondrial Fusion TRNA Threonylcarbamoyladenosine Metabolic Process Response To Radiation Response To Hydrogen Peroxide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To External Biotic Stimulus Programmed Cell Death Involved In Cell Development Regulation Of Neuron Apoptotic Process Negative Regulation Of Autophagy Cytoplasmic Dynein Complex Cellular Response To Reactive Oxygen Species Nuclear Membrane Identical Protein Binding Cytoplasm Metanephric Descending Thin Limb Development Cellular Response To Decreased Oxygen Levels	Microtubule Binding
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