DYNLL2 and HSF5

		DYNLL2	HSF5
Description		dynein light chain LC8-type 2	heat shock transcription factor 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse	XY Body Nucleus Chromosome
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Scaffold Protein Binding	DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Microtubule-based Process	Regulation Of DNA-templated Transcription Male Meiotic Nuclear Division Spermatogenesis Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Meiotic Cell Cycle
Pathways		Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
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Diseases
GWAS		Blood protein levels ( 30072576)	Cognitive function ( 25644384) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Refractive error ( 32231278) Vitamin D levels ( 25208829)
Interacting Genes		38 interacting genes: BMF C14orf119 C17orf67 CHMP5 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 F13A1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HOMER3 HSF5 IHO1 KIF2B MEOX2 MORN3 MSI2 MYO5A OTUD6A PAK1 PKIA PKIG PRKD3 RASGRP3 REDIC1 SKAP1 SMCP SPAG8 STXBP4 THAP10 TPPP XIAP ZAR1	1 interacting genes: DYNLL2
Entrez ID		140735	124535
HPRD ID		06489	19185
Ensembl ID		ENSG00000264364	ENSG00000176160
Uniprot IDs		Q96FJ2	Q4G112
PDB IDs		2XQQ 3P8M 4D07 7CNU
Enriched GO Terms of Interacting Partners?		Microtubule Binding	Myosin V Complex 9+0 Non-motile Cilium Dynein Intermediate Chain Binding Cytoplasmic Dynein Complex Microtubule Associated Complex Dynein Complex Ciliary Tip Scaffold Protein Binding Postsynaptic Density Microtubule Cytoskeleton Postsynapse Microtubule Protein-containing Complex Binding
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