HSPB3 and PRP4K

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HSPB3	PRP4K
Description		heat shock protein family B (small) member 3	pre-mRNA processing factor kinase PRP4K
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Speck	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function		Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Response To Unfolded Protein	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Hippo Signaling Positive Regulation Of Hippo Signaling MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways			mRNA Splicing - Major Pathway
Drugs			Fostamatinib
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Systolic blood pressure (dietary potassium intake interaction) ( 29212900)
Interacting Genes		19 interacting genes: ANP32A BBOX1 HSPB2 HSPB8 LRIF1 LSM14B MED31 MED8 MRPL38 NSMF OLFML3 PRP4K RAMP3 RBM48 RTL8A SETDB1 TCAP UNC119 ZZEF1	10 interacting genes: CLK1 HSPB3 KLF13 PNN POLR3F RIPK1 RNF10 SRPK2 SRSF1 YWHAG
Entrez ID		8988	8899
HPRD ID		06861	09087
Ensembl ID		ENSG00000169271	ENSG00000112739
Uniprot IDs		Q12988 Q6ICS9	Q13523
PDB IDs		6F2R	4IAN 4IFC 4IIR 4IJP 6CNH 6PJJ 6PK6 6QX9 8H6E 8H6J 8QXD 8R08 8R0A 8Y6O
Enriched GO Terms of Interacting Partners?			Regulation Of RNA Splicing Nuclear Speck Exon-exon Junction Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Peptidyl-serine Phosphorylation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Protein Serine Kinase Activity Nucleus Macromolecule Metabolic Process RNA Metabolic Process RNA Splicing Catalytic Step 2 Spliceosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Protein Localization To P-body Positive Regulation Of Neuron Apoptotic Process Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Protein Serine/threonine Kinase Activity MRNA Processing Protein Kinase C Inhibitor Activity Positive Regulation Of Interleukin-6-mediated Signaling Pathway Death Domain Binding Regulation Of MRNA Splicing, Via Spliceosome DNA Topoisomerase Binding Nuclear Speck Organization Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Regulation Of MRNA Processing Positive Regulation Of MiRNA Processing Peptidyl-serine Autophosphorylation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane
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