PRP4K and POLR3F

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		PRP4K	POLR3F
Description		pre-mRNA processing factor kinase PRP4K	RNA polymerase III subunit F
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nuclear Speck Catalytic Step 2 Spliceosome	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	DNA Binding Double-stranded DNA Binding DNA-directed RNA Polymerase Activity Protein Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Hippo Signaling Positive Regulation Of Hippo Signaling MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint	Immune System Process Regulation Of Transcription By RNA Polymerase III Transcription By RNA Polymerase III Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus
Pathways		mRNA Splicing - Major Pathway	Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs		Fostamatinib
Diseases
GWAS			Refractive error ( 32231278)
Interacting Genes		10 interacting genes: CLK1 HSPB3 KLF13 PNN POLR3F RIPK1 RNF10 SRPK2 SRSF1 YWHAG	16 interacting genes: ATPAF2 BDP1 BRF1 ERG28 GTF3C4 KAT5 LRIF1 NINL PRP4K RIN3 STC2 SUV39H2 TBP TNS2 UBE2G2 WDR89
Entrez ID		8899	10621
HPRD ID		09087	15156
Ensembl ID		ENSG00000112739	ENSG00000132664
Uniprot IDs		Q13523	A0A8V8TL53 A0A8V8TMS0 Q05DB8 Q9H1D9
PDB IDs		4IAN 4IFC 4IIR 4IJP 6CNH 6PJJ 6PK6 6QX9 8H6E 8H6J 8QXD 8R08 8R0A 8Y6O	2DK5 2YU3 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Nuclear Speck Exon-exon Junction Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Peptidyl-serine Phosphorylation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Protein Serine Kinase Activity Nucleus Macromolecule Metabolic Process RNA Metabolic Process RNA Splicing Catalytic Step 2 Spliceosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Protein Localization To P-body Positive Regulation Of Neuron Apoptotic Process Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Protein Serine/threonine Kinase Activity MRNA Processing Protein Kinase C Inhibitor Activity Positive Regulation Of Interleukin-6-mediated Signaling Pathway Death Domain Binding Regulation Of MRNA Splicing, Via Spliceosome DNA Topoisomerase Binding Nuclear Speck Organization Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Regulation Of MRNA Processing Positive Regulation Of MiRNA Processing Peptidyl-serine Autophosphorylation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane	RNA Polymerase III General Transcription Initiation Factor Activity Transcription By RNA Polymerase III Transcription Factor TFIIIB Complex Transcription Initiation At RNA Polymerase III Promoter Transcription Preinitiation Complex Assembly TRNA Transcription DNA-templated Transcription Initiation RRNA Transcription Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Chromosome, Centromeric Region Protein-DNA Complex Assembly Histone H2AK5 Acetyltransferase Activity RNA Polymerase III Preinitiation Complex Assembly Negative Regulation Of Mast Cell Chemotaxis
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