RPS6KA4 and PDE2A

		RPS6KA4	PDE2A
Description		ribosomal protein S6 kinase A4	phosphodiesterase 2A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Synaptic Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone H3S10 Kinase Activity Histone H3S28 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Magnesium Ion Binding 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity CAMP Binding CGMP Binding TPR Domain Binding Phosphate Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Negative Regulation Of Cytokine Production Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Phosphorylation Inflammatory Response Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction TORC1 Signaling Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Ventricular Septum Development Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of CGMP-mediated Signaling Negative Regulation Of CGMP-mediated Signaling Regulation Of Mitochondrion Organization CGMP-mediated Signaling Monocyte Differentiation Aorta Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability CGMP Catabolic Process Positive Regulation Of Inflammatory Response Establishment Of Endothelial Barrier Cellular Response To Mechanical Stimulus Cellular Response To CAMP Cellular Response To CGMP Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		Recycling pathway of L1	cGMP effects G alpha (s) signalling events
Drugs		Flavin mononucleotide	Caffeine Cyclic GMP ND7001 ND7001 Exisulind 3-isobutyl-1-methyl-7H-xanthine Tofisopam Doxofylline Trapidil
Diseases
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Leprosy ( 22019778) Offspring birth weight ( 31043758) Primary biliary cholangitis ( 21399635) Primary biliary cirrhosis ( 22961000) Psoriasis ( 23143594) Serum uric acid levels ( 32514006)	Household income (MTAG) ( 31844048) Optic nerve measurement (cup area) ( 20395239) Rheumatoid arthritis ( 22446963)
Interacting Genes		10 interacting genes: ATF1 CREB1 FOS HMGN1 MAP2K1 MAPK1 MAPK14 MAPK3 NEDD4 PDE2A	13 interacting genes: ANAPC15 CHEK1 FAM168A FCHSD2 FOLR1 GLS2 HSD17B6 ITSN1 LRP5 NDUFV1 RPS3 RPS6KA4 SPAG7
Entrez ID		8986	5138
HPRD ID		04677	04041
Ensembl ID		ENSG00000162302	ENSG00000186642
Uniprot IDs		A0PJF8 B4DPV1 E9PJN1 O75676	O00408 Q8IW54
PDB IDs			1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 6BLF 6C7D 6C7E 6C7F 6C7G 6C7I 6C7J 6CYB 6CYC 6CYD 6ZND 6ZQZ
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Intracellular Signaling Cassette Regulation Of Transcription By RNA Polymerase II Trachea Formation Response To Growth Factor Intracellular Signal Transduction ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Cytokine Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process MAP Kinase Activity Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Nucleobase-containing Compound Metabolic Process Response To Peptide Response To Cytokine Regulation Of Intracellular Transport Cellular Response To Tumor Necrosis Factor Face Development Animal Organ Formation Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Lung Morphogenesis Positive Regulation Of Biosynthetic Process Response To Tumor Necrosis Factor Response To Light Stimulus Enzyme-linked Receptor Protein Signaling Pathway Thyroid Gland Development Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Interleukin-34-mediated Signaling Pathway Response To Purine-containing Compound Regulation Of Stress-activated MAPK Cascade Myeloid Leukocyte Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipopolysaccharide-mediated Signaling Pathway Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Lipid ATF4-CREB1 Transcription Factor Complex DNA-templated Transcription Regulation Of Gene Expression Osteoclast Differentiation Response To Radiation	Positive Regulation Of Base-excision Repair Regulation Of Base-excision Repair Regulation Of Mitotic Nuclear Division Apoptotic Process Involved In Development Regulation Of Nuclear Division Endocytosis Receptor-mediated Endocytosis Clathrin-dependent Endocytosis Regulation Of DNA Repair Neural Crest Cell Migration Involved In Heart Formation Response To TNF Agonist Oxidized Pyrimidine DNA Binding Brexanolone Catabolic Process Stereocilium Shaft
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