FOXH1 and ACTMAP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FOXH1	ACTMAP
Description		forkhead box H1	actin maturation protease
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Activin Responsive Factor Complex	Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Nuclear Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding DNA-binding Transcription Factor Binding	Aminopeptidase Activity Initiator Methionyl Aminopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity Cysteine-type Aminopeptidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Determination Of Left/right Asymmetry In Lateral Mesoderm Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Anterior/posterior Pattern Specification Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Nodal Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Hepatocyte Differentiation Cellular Response To Cytokine Stimulus	Proteolysis Protein Processing
Pathways		Signaling by NODAL Signaling by Activin Germ layer formation at gastrulation Formation of axial mesoderm
Drugs
Diseases
GWAS		Blood metabolite levels ( 26401656) Educational attainment ( 25201988) General cognitive ability ( 29844566)
Interacting Genes		72 interacting genes: ACTMAP AOC1 ARID5A ATP23 ATXN1L BATF2 C10orf55 CEACAM6 CFAP68 CREBBP CRX CRYBA1 CYSRT1 DAZAP2 DRAP1 FAM168B FAM83A FOXD2 FOXG1 HDHD3 HEY1 HLX HOXA1 HSF4 KLHL26 KRTAP11-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP7-1 LASP1 LRRC14 MAGED1 MGAT5B MSX2 NKX2-5 NOTO OXER1 PLA2G10 PNMA5 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 RBM46 RBPMS2 RECQL4 RNF144B RPL8 SERGEF SMAD2 SMAD3 SMAD4 SOX14 SOX4 SUPT20H TEKT5 TFG TLX3 TSC1 UBAP2 UFSP1 ZC3H10 ZIC1 ZNF34 ZNF503	67 interacting genes: A1CF ABI2 AGXT ANKS1A ARID5A COL8A1 CYSRT1 DTX2 ENKD1 FAM222B FANCL FBLIM1 FNDC3B FOXH1 FRS3 GLIS2 GLYCTK GPS2 HOXC8 HR HSF4 IGFN1 INCA1 KCTD9 KPRP KRTAP23-1 KRTAP26-1 LASP1 LMO3 MISP NEDD9 NOXA1 PATZ1 PITX1 PLAC8 PLSCR3 POGZ PRKAB2 PROP1 PRR35 QRICH1 RBPMS RBPMS2 ROR2 SAXO1 SMARCD1 SNRPC SPAG8 TBX6 TCAP TCF7L2 TEKT5 TFG TLE5 TLX3 TOLLIP TRAF4 TRIP13 TROAP VAC14 VENTX WDR25 WWOX YPEL3 ZC2HC1C ZC3H10 ZMYND19
Entrez ID		8928	284325
HPRD ID		04689	13449
Ensembl ID		ENSG00000160973	ENSG00000188493
Uniprot IDs		O75593	Q5BKX5
PDB IDs		5XOC 7YZB
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Embryonic Morphogenesis Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Cardiac Conduction System Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding SMAD Protein Complex Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Cardiac Septum Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Regionalization Negative Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis I-SMAD Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Pattern Specification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Activin Responsive Factor Complex Gastrulation Paraxial Mesoderm Morphogenesis Heart Valve Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Embryonic Pattern Specification Cardiac Muscle Tissue Development SMAD Protein Signal Transduction Chromatin Binding Mesoderm Morphogenesis R-SMAD Binding Outflow Tract Septum Morphogenesis Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Muscle Cell Differentiation Regulation Of Gene Expression RNA Polymerase II Transcription Regulator Complex Tube Morphogenesis	Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Myoblast Fate Commitment Transcription Corepressor Activity Positive Regulation Of RNA Metabolic Process Chromatin
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