AKAP4 and PRKAR2B

Number of citations of the paper that reports this interaction (PubMedID 9852104)
0

Data Source:
HPRD (two hybrid, in vitro)

		AKAP4	PRKAR2B
Description		A-kinase anchoring protein 4	protein kinase cAMP-dependent type II regulatory subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Cilium CAMP-dependent Protein Kinase Complex Z Disc Motile Cilium Sperm Fibrous Sheath Sperm Flagellum Cell Projection Perinuclear Region Of Cytoplasm Sperm Midpiece Sperm Principal Piece Sperm End Piece Sperm Head-tail Coupling Apparatus	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Kinase A Binding	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Single Fertilization Intracellular Protein Localization Cell Projection Organization Flagellated Sperm Motility Establishment Of Protein Localization Establishment Of Localization In Cell Sperm Flagellum Assembly	Fatty Acid Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Negative Regulation Of CAMP/PKA Signal Transduction
Pathways			PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Cyclic adenosine monophosphate
Diseases
GWAS			Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: AKAP3 FSIP1 FSIP2 KDM6A PRKAR1A PRKAR2A PRKAR2B	25 interacting genes: ABCB4 AKAP1 AKAP10 AKAP11 AKAP14 AKAP19 AKAP4 AKAP5 AKAP9 CBR1 CFAP91 ECM1 GNAI3 KIF5B LAMB1 LASP1 LRCH4 MT1H NBEA OGT PAK1IP1 RAP2B RPL30 TAF12 TFR2
Entrez ID		8852	5577
HPRD ID		02173	01486
Ensembl ID		ENSG00000147081	ENSG00000005249
Uniprot IDs		A0A384MQY7 Q5JQC9	B3KY43 P31323
PDB IDs
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Ciliary Base Regulation Of CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Sperm Head-tail Coupling Apparatus Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Sperm Principal Piece Protein Domain Specific Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Raft Sperm Midpiece Ubiquitin Protein Ligase Binding Response To Antipsychotic Drug Axoneme Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Sperm End Piece Histone H3K27me2/H3K27me3 Demethylase Activity Centrosome Cilium Movement Negative Regulation Of Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Sperm Fibrous Sheath Cellular Response To Glucagon Stimulus Heart Development MLL3/4 Complex Negative Regulation Of Activated T Cell Proliferation Acrosome Reaction	Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Negative Regulation Of Adenylate Cyclase Activity CAMP-dependent Protein Kinase Complex
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