SOCS2 and TPD52

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SOCS2	TPD52
Description		suppressor of cytokine signaling 2	tumor protein D52
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cul5-RING Ubiquitin Ligase Complex	Cytoplasm Endoplasmic Reticulum Perinuclear Region Of Cytoplasm
	Molecular Function	Cytokine Receptor Binding Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity Phosphorylation-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Calcium Ion Binding Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Via JAK-STAT Lactation Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Intracellular Signal Transduction Erythropoietin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Mammary Gland Alveolus Development	Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis B Cell Differentiation Secretion
Pathways		Interleukin-7 signaling Neddylation Negative regulation of FLT3 Growth hormone receptor signaling	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Height ( 18391951 18391952 20881960 23563607 25282103 25429064 28552196 31562340) Hepatic lipid content in extreme obesity ( 25246029) Hip circumference adjusted for BMI ( 34021172) Joint damage in rheumatoid arthritis ( 31596875) Pubertal anthropometrics ( 23449627) Type 2 diabetes ( 30054458)	Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 31959851 31619474 31361310 29273806 27182965) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting glucose ( 34059833) Kawasaki disease ( 33772158) Lapatinib-induced hepatotoxicity ( 25987243) Metabolite levels (HVA/MHPG ratio) ( 23319000) Metabolite levels (Pyroglutamine) ( 23934736) Rheumatoid arthritis ( 30423114 24390342) Self-reported allergy ( 23817569)
Interacting Genes		22 interacting genes: ARFIP2 BMI1 EGFR EPOR ERBB3 ERBB4 GHR IGF1R INSR JAK1 JAK3 KIT MET PLA2G1B PRLR PTK2 RYBP SOCS3 STK16 TBK1 TPD52 YES1	17 interacting genes: ANXA6 AR MAL2 MAPK3 SENP2 SH3GLB1 SOCS2 SPG21 SPOP SRPK2 STUB1 THAP4 TPD52L1 TPD52L2 TPD52L3 TTPA UBC
Entrez ID		8835	7163
HPRD ID		05490	04963
Ensembl ID		ENSG00000120833	ENSG00000076554
Uniprot IDs		O14508	P55327
PDB IDs		2C9W 4JGH 5BO4 6I4X 6I5J 6I5N 7M6T 7ZLM 7ZLN 7ZLO 7ZLP 7ZLR 7ZLS
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Kinase Activity Receptor Complex Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Phosphorylation Protein Phosphatase Binding Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT ATP Binding Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Nucleotide Binding Transferase Activity Growth Hormone Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of MAPK Cascade Protein Modification Process Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Phosphate-containing Compound Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Differentiation Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Cellular Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Metabolic Process Basal Plasma Membrane Regulation Of Signal Transduction Positive Regulation Of Phosphate Metabolic Process ERBB Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process	Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Mammary Gland Alveolus Development Positive Regulation Of Macroautophagy Animal Organ Formation ERBB2 Signaling Pathway Lipid Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Stability Protein Modification By Small Protein Conjugation Insulin-like Growth Factor Receptor Signaling Pathway Prostate Induction Male Somatic Sex Determination Protein Modification Process Positive Regulation Of Autophagy Regulation Of Macroautophagy Negative Regulation Of Establishment Of Blood-brain Barrier Post-translational Protein Modification Positive Regulation Of Chaperone-mediated Protein Complex Assembly Peroxynitrite Isomerase Activity Protein Localization To Vacuolar Membrane Response To Epidermal Growth Factor
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