SOCS2 and PLA2G1B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SOCS2	PLA2G1B
Description		suppressor of cytokine signaling 2	phospholipase A2 group IB
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cul5-RING Ubiquitin Ligase Complex	Extracellular Region Extracellular Space Cell Surface
	Molecular Function	Cytokine Receptor Binding Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity Phosphorylation-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Phospholipase A2 Activity Signaling Receptor Binding Calcium Ion Binding Phospholipid Binding Hydrolase Activity Bile Acid Binding Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Via JAK-STAT Lactation Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Intracellular Signal Transduction Erythropoietin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Mammary Gland Alveolus Development	Innate Immune Response In Mucosa Neutrophil Mediated Immunity Lipid Metabolic Process Fatty Acid Biosynthetic Process Phospholipid Metabolic Process Actin Filament Organization Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Lipid Catabolic Process Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of D-glucose Import Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Positive Regulation Of Fibroblast Proliferation Arachidonate Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Podocyte Apoptotic Process
Pathways		Interleukin-7 signaling Neddylation Negative regulation of FLT3 Growth hormone receptor signaling	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA Developmental Lineage of Pancreatic Acinar Cells
Drugs			Fluocinolone acetonide Sulfasalazine Azelastine Hexane-1,6-Diol N-Tridecanoic Acid Cholic Acid P-Anisic Acid Heptanoic acid 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine Pyruvaldehyde Lpc-Ether Niflumic acid PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL Medical Cannabis
Diseases
GWAS		Height ( 18391951 18391952 20881960 23563607 25282103 25429064 28552196 31562340) Hepatic lipid content in extreme obesity ( 25246029) Hip circumference adjusted for BMI ( 34021172) Joint damage in rheumatoid arthritis ( 31596875) Pubertal anthropometrics ( 23449627) Type 2 diabetes ( 30054458)	Bipolar disorder ( 31043756)
Interacting Genes		22 interacting genes: ARFIP2 BMI1 EGFR EPOR ERBB3 ERBB4 GHR IGF1R INSR JAK1 JAK3 KIT MET PLA2G1B PRLR PTK2 RYBP SOCS3 STK16 TBK1 TPD52 YES1	5 interacting genes: BGN CSF3R PLA2G2A PLAA SOCS2
Entrez ID		8835	5319
HPRD ID		05490	01396
Ensembl ID		ENSG00000120833	ENSG00000170890
Uniprot IDs		O14508	P04054
PDB IDs		2C9W 4JGH 5BO4 6I4X 6I5J 6I5N 7M6T 7ZLM 7ZLN 7ZLO 7ZLP 7ZLR 7ZLS	3ELO 6Q42
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Kinase Activity Receptor Complex Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Phosphorylation Protein Phosphatase Binding Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT ATP Binding Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Nucleotide Binding Transferase Activity Growth Hormone Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of MAPK Cascade Protein Modification Process Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Phosphate-containing Compound Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Differentiation Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Cellular Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Metabolic Process Basal Plasma Membrane Regulation Of Signal Transduction Positive Regulation Of Phosphate Metabolic Process ERBB Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process	Cytokine Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Articular Cartilage Development Defense Response Regulation Of Developmental Process Granulocyte Colony-stimulating Factor Binding Amelogenesis Regulation Of Neutrophil Activation Intestinal Stem Cell Homeostasis Calcium-dependent Phospholipase A2 Activity Phospholipid Metabolic Process Positive Regulation Of Developmental Process Growth Hormone Receptor Binding Regulation Of Developmental Growth Regulation Of Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Erythropoietin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Growth Hormone Receptor Signaling Pathway JAK Pathway Signal Transduction Adaptor Activity Phosphorylation-dependent Protein Binding Positive Regulation Of Neuron Migration Positive Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Ubiquitin Recycling Positive Regulation Of Prostaglandin Biosynthetic Process Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Protein Polyubiquitination Phospholipase A2 Activator Activity Regulation Of Protein K63-linked Ubiquitination Low-density Lipoprotein Particle Remodeling Insulin-like Growth Factor Receptor Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mammary Gland Alveolus Development Regulation Of Cell Growth Cytokine-mediated Signaling Pathway Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Positive Regulation Of Dendrite Extension Arachidonate Secretion
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