NRP1 and TGFBR3

Number of citations of the paper that reports this interaction (PubMedID 21186301)
0

Data Source:
BioGRID (pull down)

		NRP1	TGFBR3
Description		neuropilin 1	transforming growth factor beta receptor 3
Image
GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Extracellular Space Cytoplasm Mitochondrion Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Membrane Axon Cytoplasmic Vesicle Mitochondrial Membrane Neuron Projection Receptor Complex Postsynaptic Membrane Sorting Endosome Glutamatergic Synapse	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Exosome Cell Periphery
	Molecular Function	Vascular Endothelial Growth Factor Receptor Activity GTPase Activator Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Protein Kinase Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding BMP Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Neural Crest Cell Migration Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Integrin-mediated Signaling Pathway Cell-cell Signaling Nervous System Development Axon Guidance Axonal Fasciculation Heart Development Motor Neuron Axon Guidance Response To Wounding Animal Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Facial Nerve Structural Organization Trigeminal Nerve Morphogenesis Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Cell Differentiation Negative Regulation Of Axon Extension Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Retinal Ganglion Cell Axon Guidance Regulation Of Cdc42 Protein Signal Transduction Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Neuropilin Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Positive Regulation Of Angiogenesis Symbiont Entry Into Host Cell Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Sympathetic Nervous System Development Neuron Development Axon Extension Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Chemotaxis Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Development In Camera-type Eye Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Motor Neuron Migration Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Postsynapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Basal Dendrite Development Basal Dendrite Arborization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neural Crest Cell Migration Involved In Autonomic Nervous System Development Protein Localization To Early Endosome Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Otic Placode Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Response To Hypoxia Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Positive Regulation Of Gene Expression Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Animal Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of JNK Cascade Negative Regulation Of Epithelial Cell Proliferation Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Epicardium-derived Cardiac Fibroblast Cell Development Vasculogenesis Involved In Coronary Vascular Morphogenesis Heart Trabecula Morphogenesis Secondary Palate Development Protein-containing Complex Assembly Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Extracellular Matrix Assembly
Pathways		Neurophilin interactions with VEGF and VEGFR Signaling by ROBO receptors Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Signal transduction by L1 CHL1 interactions Attachment and Entry	Signaling by Activin Signaling by Activin FGFR1b ligand binding and activation FGFR1c ligand binding and activation Signaling by BMP TGF-beta receptor signaling activates SMADs TGFBR3 PTM regulation TGFBR3 regulates TGF-beta signaling TGFBR3 expression TGFBR3 regulates FGF2 signaling TGFBR3 regulates activin signaling
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Migraine ( 27322543) Reticulocyte count ( 32888494) Schizophrenia ( 21682944) Small cell lung carcinoma ( 28604730) Tetralogy of Fallot ( 23297363) Type 1 diabetes ( 34127860) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Appendicular lean mass ( 33097823) Bone mineral density ( 19249006) Carotid plaque burden ( 28282560) dexamethasone sensitivity in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 33627673 25861811) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung function (FEV1/FVC) ( 30804560 28166213) Lung function (FVC) ( 26635082 30804560) Metamizole-induced agranulocytosis or neutropenia ( 33138277) Multiple sclerosis ( 31604244) Optic disc area ( 25631615 21307088 28073927 31798171) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Peak expiratory flow ( 30804560) Pulse pressure ( 30224653) QT interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Type 2 diabetes ( 23209189) Vertical cup-disc ratio ( 31798171 28073927 25241763) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		31 interacting genes: CACNB2 FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM MSRB2 NEBL NRP2 PGF PLXNA1 PLXNB1 PTER RPL27 SEMA3A SEMA3B SEMA3C SEMA3F SNCA SNX5 SNX6 TGFBR1 TGFBR2 TGFBR3 USP9X VEGFA VEGFB	13 interacting genes: ACVR2A ARRB2 DYNLT4 ENG GIPC1 INHA INHBA NRP1 SDC2 TGFB1 TGFB2 TGFB3 TGFBR2
Entrez ID		8829	7049
HPRD ID		03642	02846
Ensembl ID		ENSG00000099250	ENSG00000069702
Uniprot IDs		A8K9V7 E9PEP6 O14786 Q59F20 Q6X907	A0A0A8KWK3 Q03167
PDB IDs		1KEX 2QQI 2QQM 2QQN 3I97 4DEQ 4RN5 5C7G 5IJR 5IYY 5J1X 5JGI 5JGQ 5JHK 5L73 6FMC 6FMF 6TKK 7JJC 7O1N 7P5U 8C5G 8PFE 9EOU	7LBG
Enriched GO Terms of Interacting Partners?		Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Semaphorin-plexin Signaling Pathway Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Heparin Binding Chemotaxis Cell Motility Cell Surface Receptor Signaling Pathway Locomotion Vascular Endothelial Growth Factor Signaling Pathway Tissue Morphogenesis Positive Regulation Of Cell Division Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Regulation Of Chemotaxis Neuropilin Binding Angiogenesis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Region Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Semaphorin Receptor Binding Lung Development Anatomical Structure Morphogenesis Regulation Of Cell Division Positive Regulation Of Vasculature Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelial Cell Migration Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphate Metabolic Process Chemoattractant Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Developmental Growth Involved In Morphogenesis Neuron Projection Guidance Positive Regulation Of MAPK Cascade Morphogenesis Of An Epithelium Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus	Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Type III Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Type I Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Outflow Tract Septum Morphogenesis Gland Morphogenesis Odontogenesis Regulation Of Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Multicellular Organismal Process Heart Development Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Animal Organ Morphogenesis Salivary Gland Morphogenesis Positive Regulation Of Developmental Process Activin Binding Response To Growth Factor Growth Factor Activity Negative Regulation Of Macrophage Cytokine Production Cell Surface Receptor Signaling Pathway Animal Organ Development Negative Regulation Of Cytokine Production Secondary Palate Development Anatomical Structure Morphogenesis Artery Morphogenesis Vasculogenesis Positive Regulation Of Cardiocyte Differentiation Transforming Growth Factor Beta Receptor Binding System Development Cardiac Septum Morphogenesis Response To Wounding Roof Of Mouth Development Cytokine Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?