TGFBR3 and ENG

Number of citations of the paper that reports this interaction (PubMedID 12568406)
0

Data Source:
HPRD (in vivo)

		TGFBR3	ENG
Description		transforming growth factor beta receptor 3	endoglin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Exosome Cell Periphery	Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Receptor Complex Endothelial Microparticle
	Molecular Function	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding BMP Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III	Transmembrane Signaling Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Coreceptor Activity Signaling Receptor Activator Activity Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Identical Protein Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Response To Hypoxia Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Positive Regulation Of Gene Expression Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Animal Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of JNK Cascade Negative Regulation Of Epithelial Cell Proliferation Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Epicardium-derived Cardiac Fibroblast Cell Development Vasculogenesis Involved In Coronary Vascular Morphogenesis Heart Trabecula Morphogenesis Secondary Palate Development Protein-containing Complex Assembly Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Extracellular Matrix Assembly	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Heart Looping Sprouting Angiogenesis Positive Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Extracellular Matrix Disassembly Regulation Of Cell Adhesion Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Dorsal Aorta Morphogenesis Wound Healing Regulation Of Cell Population Proliferation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Cell Motility Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Atrial Cardiac Muscle Tissue Morphogenesis Cell Chemotaxis Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Detection Of Hypoxia Endocardial Cushion To Mesenchymal Transition Vascular Associated Smooth Muscle Cell Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Atrioventricular Canal Morphogenesis Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Signaling by Activin Signaling by Activin FGFR1b ligand binding and activation FGFR1c ligand binding and activation Signaling by BMP TGF-beta receptor signaling activates SMADs TGFBR3 PTM regulation TGFBR3 regulates TGF-beta signaling TGFBR3 expression TGFBR3 regulates FGF2 signaling TGFBR3 regulates activin signaling
Drugs			Carotuximab
Diseases			Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Appendicular lean mass ( 33097823) Bone mineral density ( 19249006) Carotid plaque burden ( 28282560) dexamethasone sensitivity in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 33627673 25861811) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung function (FEV1/FVC) ( 30804560 28166213) Lung function (FVC) ( 26635082 30804560) Metamizole-induced agranulocytosis or neutropenia ( 33138277) Multiple sclerosis ( 31604244) Optic disc area ( 25631615 21307088 28073927 31798171) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Peak expiratory flow ( 30804560) Pulse pressure ( 30224653) QT interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Type 2 diabetes ( 23209189) Vertical cup-disc ratio ( 31798171 28073927 25241763) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Blood protein levels ( 30072576) Body mass index ( 26426971) Metabolic syndrome ( 20694148) Monocyte count ( 32888494)
Interacting Genes		13 interacting genes: ACVR2A ARRB2 DYNLT4 ENG GIPC1 INHA INHBA NRP1 SDC2 TGFB1 TGFB2 TGFB3 TGFBR2	16 interacting genes: ACVR1 ACVR2A BMP2 BMP7 CNTRL DYNLT4 GDF2 INHBA LHX2 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 TRAF1
Entrez ID		7049	2022
HPRD ID		02846	00565
Ensembl ID		ENSG00000069702	ENSG00000106991
Uniprot IDs		A0A0A8KWK3 Q03167	B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0
PDB IDs		7LBG	5HZV 5HZW 5I04
Enriched GO Terms of Interacting Partners?		Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Type III Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Type I Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Outflow Tract Septum Morphogenesis Gland Morphogenesis Odontogenesis Regulation Of Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Multicellular Organismal Process Heart Development Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Animal Organ Morphogenesis Salivary Gland Morphogenesis Positive Regulation Of Developmental Process Activin Binding Response To Growth Factor Growth Factor Activity Negative Regulation Of Macrophage Cytokine Production Cell Surface Receptor Signaling Pathway Animal Organ Development Negative Regulation Of Cytokine Production Secondary Palate Development Anatomical Structure Morphogenesis Artery Morphogenesis Vasculogenesis Positive Regulation Of Cardiocyte Differentiation Transforming Growth Factor Beta Receptor Binding System Development Cardiac Septum Morphogenesis Response To Wounding Roof Of Mouth Development Cytokine Activity	Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Response To Growth Factor Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Animal Organ Development Type II Transforming Growth Factor Beta Receptor Binding Activin Receptor Signaling Pathway Activin Binding Type III Transforming Growth Factor Beta Receptor Binding Epithelial To Mesenchymal Transition Odontogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Mesenchymal Cell Differentiation Animal Organ Morphogenesis Transforming Growth Factor Beta Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Intracellular Signal Transduction Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Cell Differentiation Tissue Morphogenesis Heart Development Cardiac Septum Morphogenesis Gland Morphogenesis Growth Factor Activity Cellular Response To BMP Stimulus Positive Regulation Of Developmental Process Roof Of Mouth Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition BMP Signaling Pathway Tube Morphogenesis Salivary Gland Morphogenesis Regulation Of Multicellular Organismal Development Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Secondary Palate Development Regulation Of Cell Differentiation Cytokine Activity Positive Regulation Of Signal Transduction
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