RGS9 and GUCY2D

Number of citations of the paper that reports this interaction (PubMedID 11485301)
0

Data Source:
HPRD (in vivo)

		RGS9	GUCY2D
Description		regulator of G protein signaling 9	guanylate cyclase 2D, retinal
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Presynaptic Membrane Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse	Photoreceptor Outer Segment Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Photoreceptor Outer Segment Membrane Cell Projection Photoreceptor Disc Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Nervous System Development Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Response To Estradiol Intracellular Signal Transduction Light Adaption Regulation Of Calcium Ion Export Across Plasma Membrane Dark Adaptation	CGMP Biosynthetic Process Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Regulation Of Opsin-mediated Signaling Pathway Intracellular Signal Transduction
Pathways		G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Inactivation, recovery and regulation of the phototransduction cascade
Drugs
Diseases		Bradyopsia	Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Adverse response to antithyroid drugs in Graves disease ( 30067105) Heel bone mineral density ( 28869591 30598549)	Refractive error ( 32231278)
Interacting Genes		6 interacting genes: ADRB2 DRD3 GNAT1 GNB5 GUCY2D RGS9BP	5 interacting genes: GUCA1A GUCA1B GUCA2B RGS9 S100B
Entrez ID		8787	3000
HPRD ID		04962	02550
Ensembl ID		ENSG00000108370	ENSG00000132518
Uniprot IDs		A8K1G1 O75916	Q02846
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Response To Light Stimulus Response To Radiation Photoreceptor Outer Segment Membrane Regulation Of Opsin-mediated Signaling Pathway Response To Light Intensity System Process G Protein-coupled Dopamine Receptor Signaling Pathway Visual Perception Detection Of Light Stimulus Involved In Visual Perception Sensory Perception Of Light Stimulus Photoreceptor Disc Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Nervous System Process Negative Regulation Of Blood Pressure Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Metal Ion Transport Detection Of Light Stimulus Visual Behavior Photoreceptor Outer Segment Signal Transduction Regulation Of Monoatomic Ion Transport Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity GTPase Activator Complex G-protein Gamma-subunit Binding Sensory Perception Beta2-adrenergic Receptor Activity Musculoskeletal Movement, Spinal Reflex Action Acyl Binding Cellular Response To Light Stimulus Background Adaptation Dark Adaptation Detection Of Abiotic Stimulus Regulation Of Signal Transduction Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Neural Tissue Regeneration Detection Of Stimulus Involved In Sensory Perception Light Adaption Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Psychosocial Stress Regulation Of Cell Communication Norepinephrine Binding Regulation Of Blood Pressure Positive Regulation Of Lipophagy	Guanylate Cyclase Regulator Activity Calcium Sensitive Guanylate Cyclase Activator Activity Cone Photoreceptor Outer Segment System Process Visual Perception Sensory Perception Of Light Stimulus Photoreceptor Disc Membrane Nervous System Process Phototransduction Response To Light Stimulus Photoreceptor Inner Segment Detection Of Light Stimulus Response To Radiation Photoreceptor Outer Segment Sensory Perception Body Fluid Secretion Positive Regulation Of Guanylate Cyclase Activity Calcium Ion Binding Detection Of Abiotic Stimulus Dark Adaptation Light Adaption Guanylate Cyclase Activator Activity Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of CGMP-mediated Signaling Detection Of Stimulus Microtubule Cytoskeleton Negative Regulation Of Skeletal Muscle Cell Differentiation Reduction Of Food Intake In Response To Dietary Excess Regulation Of Body Fluid Levels Ciliary Basal Body Receptor Guanylyl Cyclase Signaling Pathway RAGE Receptor Binding Regulation Of CGMP-mediated Signaling Regulation Of Signal Transduction S100 Protein Binding Response To Light Intensity Developmental Growth Positive Regulation Of Myelination Regulation Of Cell Communication Positive Regulation Of Lyase Activity Positive Regulation Of Cyclase Activity Regulation Of Signaling Renal Sodium Ion Transport Renal Sodium Ion Absorption Regulation Of Skeletal Muscle Cell Differentiation Adaptive Thermogenesis G Protein-coupled Dopamine Receptor Signaling Pathway
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