TNFRSF14 and POLR1A

		TNFRSF14	POLR1A
Description		TNF receptor superfamily member 14	RNA polymerase I subunit A
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	DNA-directed RNA Polymerase Complex Chromatin Nucleus Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding Receptor Ligand Activity	Magnesium Ion Binding DNA Binding Chromatin Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity 5'-3' RNA Polymerase Activity Metal Ion Binding DNA/RNA Hybrid Binding
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration	DNA-templated Transcription Transcription By RNA Polymerase I Nucleolar Large RRNA Transcription By RNA Polymerase I Negative Regulation Of Protein Localization To Nucleolus
Pathways		TNFs bind their physiological receptors Co-inhibition by BTLA Co-inhibition by BTLA	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Autoimmune thyroid disease ( 32581359) Body mass index ( 26426971) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 28445677) Primary sclerosing cholangitis ( 23603763) Rheumatoid arthritis ( 24390342 24449572 18794853 30423114) Ulcerative colitis ( 26398853 28067908 23128233 21297633)	Facial emotion recognition (sad faces) ( 28608620)
Interacting Genes		39 interacting genes: A2M ANGPTL7 APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ENO1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MASP2 MBTPS1 NDST2 NDUFS2 NID2 NRIP1 POLR1A RAD21 RPL22 SERPINA4 SRM TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 UNC93A VIM WDR73 ZBTB48	11 interacting genes: ANP32B DYDC2 MEOX2 NFKBIB NOLC1 POLR1E PTEN RRN3 SKP2 TCF4 TNFRSF14
Entrez ID		8764	25885
HPRD ID		04122	10161
Ensembl ID		ENSG00000157873	ENSG00000068654
Uniprot IDs		B9A034 Q92956	O95602
PDB IDs		1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3 7MSG	7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Identical Protein Binding CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Signaling Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Apoptotic Process Regulation Of DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Tumor Necrosis Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Histone Deacetylase Complex Apoptotic Process Nitric-oxide Synthase Regulator Activity Programmed Cell Death Cell Death Transcription Corepressor Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Glial Cell Apoptotic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Apoptotic Signaling Pathway Enzyme Binding Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Immune System Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Type II Interferon Production Immune System Process Regulation Of ATP Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity	Protein-DNA Complex Assembly Nucleolus Organization Transcription Initiation At RNA Polymerase I Promoter RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase Binding Molecular Function Inhibitor Activity Nucleolus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Transcription Preinitiation Complex Assembly RNA Polymerase I General Transcription Initiation Factor Binding Positive Regulation Of Macromolecule Metabolic Process Roof Of Mouth Development Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Adaptive Immune Memory Response DNA-templated Transcription Initiation Nucleus Organization Beta-catenin Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Beta-catenin-TCF7L2 Complex RNA Polymerase I Core Binding Positive Regulation Of Metabolic Process
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