TNFRSF14 and ANGPTL7

		TNFRSF14	ANGPTL7
Description		TNF receptor superfamily member 14	angiopoietin like 7
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding Receptor Ligand Activity	Protein Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration	Response To Oxidative Stress Blood Coagulation Negative Regulation Of Vasculature Development Involved In Avascular Cornea Development In Camera-type Eye Regulation Of Extracellular Matrix Organization
Pathways		TNFs bind their physiological receptors Co-inhibition by BTLA Co-inhibition by BTLA
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Autoimmune thyroid disease ( 32581359) Body mass index ( 26426971) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 28445677) Primary sclerosing cholangitis ( 23603763) Rheumatoid arthritis ( 24390342 24449572 18794853 30423114) Ulcerative colitis ( 26398853 28067908 23128233 21297633)	Beard thickness ( 26926045) Intraocular pressure ( 29617998)
Interacting Genes		39 interacting genes: A2M ANGPTL7 APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ENO1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MASP2 MBTPS1 NDST2 NDUFS2 NID2 NRIP1 POLR1A RAD21 RPL22 SERPINA4 SRM TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 UNC93A VIM WDR73 ZBTB48	4 interacting genes: ACTN2 APP FBXO7 TNFRSF14
Entrez ID		8764	10218
HPRD ID		04122	10818
Ensembl ID		ENSG00000157873	ENSG00000171819
Uniprot IDs		B9A034 Q92956	O43827
PDB IDs		1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3 7MSG
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Identical Protein Binding CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Signaling Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Apoptotic Process Regulation Of DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Tumor Necrosis Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Histone Deacetylase Complex Apoptotic Process Nitric-oxide Synthase Regulator Activity Programmed Cell Death Cell Death Transcription Corepressor Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Glial Cell Apoptotic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Apoptotic Signaling Pathway Enzyme Binding Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Immune System Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Type II Interferon Production Immune System Process Regulation Of ATP Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity	Platelet Alpha Granule Lumen Actin Filament Uncapping Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Cell Activation Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of T Cell Migration Regulation Of Lymphocyte Migration Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Defense Response To Gram-negative Bacterium Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Defense Response To Gram-positive Bacterium Positive Regulation Of Supramolecular Fiber Organization Titin Z Domain Binding Dendritic Spine Integrin Binding Phospholipase C-activating Angiotensin-activated Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Receptor Ligand Activity Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Lymphocyte Activation Negative Regulation Of Adaptive Immune Memory Response Lewy Body Core Regulation Of Intrinsic Apoptotic Signaling Pathway Microspike Assembly Negative Regulation Of Protein Localization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Locomotion Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response
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