PABPC4 and HCRTR1

		PABPC4	HCRTR1
Description		poly(A) binding protein cytoplasmic 4	hypocretin receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	Plasma Membrane Membrane Synapse
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding	G Protein-coupled Receptor Activity Protein Binding Orexin Receptor Activity Peptide Hormone Binding
	Biological Process	RNA Processing RNA Catabolic Process Translation Blood Coagulation Regulation Of MRNA Stability Myeloid Cell Development	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of ERK1 And ERK2 Cascade
Pathways			Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs			Suvorexant Lemborexant Daridorexant
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 21300955 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coffee consumption ( 31046077) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) HDL cholesterol ( 30275531 24097068 25961943 20686565) HDL cholesterol levels ( 32203549 30698716 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29615537) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Red cell distribution width ( 27863252 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Walking pace ( 33128006)	Adiponectin levels ( 33562295) Asthma ( 31959851) Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Daytime nap ( 33568662) General cognitive ability ( 29844566) Hypoalbuminemia ( 34050200)
Interacting Genes		31 interacting genes: CDC27 CDC42 CEBPA DUX4 EEF1A1 FOXD3 GDF9 HAP1 HCRTR1 IL7R LUC7L2 MED31 MKNK1 MKRN3 MTF1 NMNAT1 OGT PHLDA1 PRKCG RIF1 S100A8 SETDB1 SMAD9 SREK1 SRPK2 TRIM37 UBC UBXN7 VPS26B XRN1 ZNF655	7 interacting genes: ARRB1 ARRB2 ATP1B1 CNR1 HCRT IFNGR2 PABPC4
Entrez ID		8761	3061
HPRD ID		04557	03863
Ensembl ID		ENSG00000090621	ENSG00000121764
Uniprot IDs		Q13310	A6NMV7 O43613
PDB IDs			4ZJ8 4ZJC 6TO7 6TOD 6TOS 6TOT 6TP3 6TP4 6TP6 6TQ4 6TQ6 6TQ7 6TQ9 6V9S
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm	Angiotensin Receptor Binding Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Regulation Of System Process Positive Regulation Of Receptor Internalization Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Muscle System Process Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Positive Regulation Of Transport Cytoplasmic Vesicle Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Endocytic Vesicle Membrane Receptor Internalization Regulation Of Receptor Internalization G Protein-coupled Receptor Binding Negative Regulation Of DNA-binding Transcription Factor Activity Clathrin-coated Pit Negative Regulation Of Protein Ubiquitination Regulation Of Cardiac Muscle Hypertrophy Excitatory Postsynaptic Potential Type 1 Orexin Receptor Binding Type 2 Orexin Receptor Binding Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Negative Regulation Of Post-translational Protein Modification Regulation Of Postsynaptic Membrane Potential Protein Transport Into Plasma Membrane Raft Cannabinoid Receptor Activity Type II Interferon Receptor Activity Poly(C) RNA Binding Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Synaptic Transmission, Dopaminergic Cannabinoid Signaling Pathway Retrograde Trans-synaptic Signaling By Endocannabinoid Signal Transduction Import Into Cell Regulation Of Interleukin-6 Production Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Into Membrane Raft Positive Regulation Of Endocytosis Regulation Of Transport Cytoplasmic Vesicle Membrane Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Potassium Ion Import Across Plasma Membrane Cell Communication Protein Localization To Plasma Membrane Raft Neuronal Dense Core Vesicle Lumen
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