PABPC4 and MTF1

		PABPC4	MTF1
Description		poly(A) binding protein cytoplasmic 4	metal regulatory transcription factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Acetyltransferase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	RNA Processing RNA Catabolic Process Translation Blood Coagulation Regulation Of MRNA Stability Myeloid Cell Development	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Central Nervous System Development Response To Metal Ion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Cadmium Ion Cellular Response To Zinc Ion Cartilage Homeostasis
Pathways			PPARA activates gene expression Activation of gene expression by SREBF (SREBP) MTF1 activates gene expression MTF1 activates gene expression
Drugs			Silver
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 21300955 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coffee consumption ( 31046077) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) HDL cholesterol ( 30275531 24097068 25961943 20686565) HDL cholesterol levels ( 32203549 30698716 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29615537) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Red cell distribution width ( 27863252 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Walking pace ( 33128006)	Eyebrow thickness ( 26926045) Hypothyroidism ( 22493691 27182965) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 33536424)
Interacting Genes		31 interacting genes: CDC27 CDC42 CEBPA DUX4 EEF1A1 FOXD3 GDF9 HAP1 HCRTR1 IL7R LUC7L2 MED31 MKNK1 MKRN3 MTF1 NMNAT1 OGT PHLDA1 PRKCG RIF1 S100A8 SETDB1 SMAD9 SREK1 SRPK2 TRIM37 UBC UBXN7 VPS26B XRN1 ZNF655	3 interacting genes: AP1M1 LATS1 PABPC4
Entrez ID		8761	4520
HPRD ID		04557	02546
Ensembl ID		ENSG00000090621	ENSG00000188786
Uniprot IDs		Q13310	Q14872
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm	Poly(C) RNA Binding Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis
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