CBR1 and PRKAR2B

		CBR1	PRKAR2B
Description		carbonyl reductase 1	protein kinase cAMP-dependent type II regulatory subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Extracellular Vesicle	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Postsynapse Glutamatergic Synapse
	Molecular Function	Carbonyl Reductase (NADPH) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Prostaglandin E2 9-reductase Activity S-nitrosoglutathione Reductase (NADPH) Activity	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Lipid Metabolic Process Xenobiotic Metabolic Process Glucocorticoid Metabolic Process Epithelial Cell Differentiation Vitamin K Metabolic Process Prostanoid Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Fatty Acid Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Rutin Resveratrol Heptaethylene glycol 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 Quercetin 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol Curcumin Curcumin sulfate	Cyclic adenosine monophosphate
Diseases
GWAS		Blood protein levels ( 30072576) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497)	Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		19 interacting genes: AGTR1 CHAF1B ERBB2 ERCC8 HRK HTR2B JAK1 LZTS1 OGT PAX6 PRKAR2B PTPRF RANBP9 RNF26 RPS24 STAT5B UBC USP7 VHL	25 interacting genes: ABCB4 AKAP1 AKAP10 AKAP11 AKAP14 AKAP19 AKAP4 AKAP5 AKAP9 CBR1 CFAP91 ECM1 GNAI3 KIF5B LAMB1 LASP1 LRCH4 MT1H NBEA OGT PAK1IP1 RAP2B RPL30 TAF12 TFR2
Entrez ID		873	5577
HPRD ID		00267	01486
Ensembl ID		ENSG00000159228	ENSG00000005249
Uniprot IDs		A0A384NL53 P16152	B3KY43 P31323
PDB IDs		1WMA 2PFG 3BHI 3BHJ 3BHM 4Z3D
Enriched GO Terms of Interacting Partners?		Protein Modification Process Transcription-coupled Nucleotide-excision Repair Response To Stress Growth Hormone Receptor Signaling Pathway Via JAK-STAT Nucleoplasm Negative Regulation Of Autophagy Regulation Of TORC1 Signaling Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Growth Hormone Receptor Signaling Pathway Regulation Of Lipid Metabolic Process Protein Ubiquitination Protein Metabolic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Developmental Process Regulation Of TOR Signaling Regulation Of Epithelial Cell Proliferation Negative Regulation Of Catabolic Process Protein Modification By Small Protein Conjugation Angiotensin Type I Receptor Activity Regulation Of Transcription-coupled Nucleotide-excision Repair Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Chondroitin Sulfate Proteoglycan Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Epithelial Cell Proliferation Proteolysis Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Negative Regulation Of Adenylate Cyclase Activity CAMP-dependent Protein Kinase Complex
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