CBR1

Description		carbonyl reductase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Extracellular Vesicle
	Molecular Function	Carbonyl Reductase (NADPH) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Prostaglandin E2 9-reductase Activity S-nitrosoglutathione Reductase (NADPH) Activity
	Biological Process	Lipid Metabolic Process Xenobiotic Metabolic Process Glucocorticoid Metabolic Process Epithelial Cell Differentiation Vitamin K Metabolic Process Prostanoid Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Rutin Resveratrol Heptaethylene glycol 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 Quercetin 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol Curcumin Curcumin sulfate
Diseases
GWAS		Blood protein levels ( 30072576) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497)
Novel Interacting Genes		19 novel interacting genes: AGTR1 CHAF1B ERBB2 ERCC8 HRK HTR2B JAK1 LZTS1 OGT PAX6 PRKAR2B PTPRF RANBP9 RNF26 RPS24 STAT5B UBC USP7 VHL
Interacting Genes		19 interacting genes: AGTR1 CHAF1B ERBB2 ERCC8 HRK HTR2B JAK1 LZTS1 OGT PAX6 PRKAR2B PTPRF RANBP9 RNF26 RPS24 STAT5B UBC USP7 VHL
Entrez ID		873
HPRD ID		00267
Ensembl ID		ENSG00000159228
Uniprot IDs		A0A384NL53 P16152
PDB IDs		1WMA 2PFG 3BHI 3BHJ 3BHM 4Z3D
Enriched GO Terms of Interacting Partners?		Protein Modification Process Transcription-coupled Nucleotide-excision Repair Response To Stress Growth Hormone Receptor Signaling Pathway Via JAK-STAT Nucleoplasm Negative Regulation Of Autophagy Regulation Of TORC1 Signaling Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Growth Hormone Receptor Signaling Pathway Regulation Of Lipid Metabolic Process Protein Ubiquitination Protein Metabolic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Developmental Process Regulation Of TOR Signaling Regulation Of Epithelial Cell Proliferation Negative Regulation Of Catabolic Process Protein Modification By Small Protein Conjugation Angiotensin Type I Receptor Activity Regulation Of Transcription-coupled Nucleotide-excision Repair Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Chondroitin Sulfate Proteoglycan Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Epithelial Cell Proliferation Proteolysis Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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