URI1 and DMAP1

Number of citations of the paper that reports this interaction (PubMedID 15367675)
30

Data Source:
BioGRID (pull down, affinity chromatography technology, two hybrid)
HPRD (in vivo, two hybrid, in vitro)

		URI1	DMAP1
Description		URI1 prefoldin like chaperone	DNA methyltransferase 1 associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Dendrite Protein-containing Complex Cell Projection Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex	Nucleosome Swr1 Complex Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol NuA4 Histone Acetyltransferase Complex
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Transcription Corepressor Activity Protein Phosphatase Inhibitor Activity Protein Binding Phosphatase Inhibitor Activity Phosphoprotein Binding	Transcription Corepressor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Regulation Of Transcription By RNA Polymerase II Response To Virus Negative Regulation Of Phosphatase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Stabilization Cellular Response To Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Positive Regulation Of Protein Import Into Nucleus Regulation Of Apoptotic Process Response To Ethanol Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways			HATs acetylate histones
Drugs
Diseases
GWAS		Body mass index ( 26426971) Cerebrospinal P-tau181p levels ( 28247064) Diastolic blood pressure ( 27841878) Serum urate levels in chronic kidney disease ( 30181573)	Metabolite levels ( 23823483)
Interacting Genes		12 interacting genes: AKT1 APP ATF7 DMAP1 GTF2F2 ITCH MEGF8 NEDD4 POLR2E RPS6KB1 STAP1 TRIM28	41 interacting genes: ARFIP2 BFSP2 BTG3 C1orf216 CCHCR1 CDCA7L CEBPB DAXX DNMT1 DRC4 EXOC8 GINS4 HDAC2 HSF2BP HSPB1 ING1 KRT75 LMNB1 LRSAM1 MIS18A MNAT1 MORF4L1 MRGBP NAP1L2 OGT PFDN1 PIBF1 RGS6 SAAL1 SBK3 SUOX TCEANC TCHP TLK2 TOMM34 TRIM21 TSG101 TSGA10IP TXLNA TXLNB URI1
Entrez ID		8725	55929
HPRD ID		11943	05465
Ensembl ID		ENSG00000105176	ENSG00000178028
Uniprot IDs		O94763	Q9NPF5
PDB IDs			3HM5 4IEJ 8QR1 8X15 8X19 8X1C 8XVG 8XVT 9C57 9C62 9C6N
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Protein Catabolic Process Protein-containing Complex Regulation Of Protein Localization To Nucleus Positive Regulation Of Transport Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Protein K29-linked Ubiquitination Negative Regulation Of Cell Communication Regulation Of TORC2 Signaling Positive Regulation Of Protein Localization To Nucleus Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Biosynthetic Process Regulation Of Protein Catabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Intracellular Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Enzyme Binding Macromolecule Metabolic Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Protein Metabolic Process Defense Response Post-translational Protein Modification Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Protein Localization Nucleoplasm Positive Regulation Of Defense Response Cell Cortex Negative Regulation Of Macromolecule Biosynthetic Process Proteasomal Protein Catabolic Process Negative Regulation Of Mononuclear Cell Migration	Sin3-type Complex Chromatin Organization Negative Regulation Of Stem Cell Population Maintenance
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