B4GALT2 and GUCA2B

		B4GALT2	GUCA2B
Description		beta-1,4-galactosyltransferase 2	guanylate cyclase activator 2B
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Golgi Apparatus Membrane Golgi Cisterna Membrane	Extracellular Region Extracellular Exosome
	Molecular Function	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Protein Binding Galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding	Protein Binding Guanylate Cyclase Activator Activity
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Brain Development Memory Locomotory Behavior Visual Learning Cerebellar Purkinje Cell Layer Development Glycosylation	Reduction Of Food Intake In Response To Dietary Excess Body Fluid Secretion Response To Glucose CGMP-mediated Signaling Multicellular Organism Growth Glucose Homeostasis Negative Regulation Of Blood Pressure Adipose Tissue Development Renal Sodium Ion Absorption Energy Homeostasis
Pathways		Keratan sulfate biosynthesis N-Glycan antennae elongation	Digestion
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576)	Apolipoprotein A1 levels ( 32203549)
Interacting Genes		13 interacting genes: ADGRB2 DES GPR35 GUCA2B ITSN2 KLK13 MAGOH MATN1 MEOX2 PFDN6 SLC39A14 TRIM63 USO1	5 interacting genes: B4GALT2 DPCD GUCY2D UBQLN1 UBQLN2
Entrez ID		8704	2981
HPRD ID		04928	03170
Ensembl ID		ENSG00000117411	ENSG00000044012
Uniprot IDs		O60909	Q16661
PDB IDs			1UYA 1UYB
Enriched GO Terms of Interacting Partners?		Contractile Muscle Fiber	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Organization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Peptide Receptor Activity N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Lactose Synthase Activity Third Ventricle Development Positive Regulation Of Proteolysis Vacuole Organization Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Galactosyltransferase Activity Guanylate Cyclase Activity Photoreceptor Outer Segment Membrane Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Opsin-mediated Signaling Pathway Cerebellar Purkinje Cell Layer Development Autophagy CGMP Biosynthetic Process Lateral Ventricle Development Left/right Pattern Formation Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Receptor Internalization Regulation Of Autophagy Regulation Of Clathrin-dependent Endocytosis CGMP Metabolic Process Phosphorus-oxygen Lyase Activity Ventricular System Development Negative Regulation Of Transport Photoreceptor Disc Membrane Cyclic Nucleotide Biosynthetic Process
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