EIF3I and EXOSC6

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		EIF3I	EXOSC6
Description		eukaryotic translation initiation factor 3 subunit I	exosome component 6
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	RNA Binding RNA Exonuclease Activity
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation	DNA Metabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U4 SnRNA 3'-end Processing DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)
Interacting Genes		16 interacting genes: EIF3A EIF3B EIF4G1 ERCC6 ESR1 EXOSC6 IPO13 KDM4A LIG4 METTL3 NEDD8 PAXIP1 SUMO4 TGFB1 TGFBR2 UBC	34 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		8668	118460
HPRD ID		04884	12107
Ensembl ID		ENSG00000084623	ENSG00000223496
Uniprot IDs		A0A7I2YQI2 Q13347 Q5U0F4	Q5RKV6
PDB IDs		6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8XXN 9BLN	2NN6 6D6Q 6D6R 6H25 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Positive Regulation Of DNA Recombination Cytoplasmic Translational Initiation Regulation Of DNA Recombination Response To Ionizing Radiation Regulation Of Isotype Switching Positive Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Type III Transforming Growth Factor Beta Receptor Binding Langerhans Cell Differentiation Viral Translational Termination-reinitiation Translation Initiation Factor Activity Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Immunoglobulin Production Vasculogenesis Connective Tissue Development Response To Radiation Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Type I Transforming Growth Factor Beta Receptor Binding IRES-dependent Viral Translational Initiation Regulation Of Immunoglobulin Production Translational Initiation Branch Elongation Of An Epithelium Respiratory Tube Development Positive Regulation Of B Cell Activation Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Fibroblast Proliferation Regulation Of Lymphocyte Activation Eukaryotic Translation Initiation Factor 3 Complex Regulation Of Gene Expression Eukaryotic 48S Preinitiation Complex Positive Regulation Of DNA Metabolic Process Eukaryotic 43S Preinitiation Complex Regulation Of Translational Initiation Regulation Of Macromolecule Biosynthetic Process Axis Elongation Branching Involved In Mammary Gland Duct Morphogenesis Neurogenesis Macromolecule Biosynthetic Process Myeloid Dendritic Cell Differentiation Translation Initiation Factor Binding Regulation Of Protein Metabolic Process Branching Morphogenesis Of An Epithelial Tube Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Lymphocyte Mediated Immunity	Exosome (RNase Complex) RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance MRNA Metabolic Process Cytoplasmic Exosome (RNase Complex) Nucleobase-containing Compound Catabolic Process Nucleolar Exosome (RNase Complex) Nuclear RNA Surveillance RNA Surveillance RNA Exonuclease Activity RRNA Catabolic Process U4 SnRNA 3'-end Processing RNA Binding RNA Metabolic Process SnRNA Metabolic Process 3'-5'-RNA Exonuclease Activity Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Processing Macromolecule Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing RRNA 3'-end Processing TRNA Decay MRNA 3'-UTR AU-rich Region Binding RRNA Metabolic Process SnRNA Processing Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process RRNA Processing Catabolic Process Macromolecule Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Negative Regulation Of Gene Expression U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Histone MRNA Catabolic Process Sno(s)RNA Metabolic Process CUT Catabolic Process Histone MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA Binding Nucleolus
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