EXOSC6 and NDUFA13

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		EXOSC6	NDUFA13
Description		exosome component 6	NADH:ubiquinone oxidoreductase subunit A13
Image
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex I Respiratory Chain Complex
	Molecular Function	RNA Binding RNA Exonuclease Activity	Protein Binding ATP Binding Endopeptidase Activator Activity
	Biological Process	DNA Metabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U4 SnRNA 3'-end Processing DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing	Apoptotic Process Aerobic Respiration Mitochondrial Respiratory Chain Complex I Assembly Cellular Response To Interferon-beta Proton Motive Force-driven Mitochondrial ATP Synthesis Protein Insertion Into Mitochondrial Inner Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Retinoic Acid Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation
Drugs			NADH
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Platelet count ( 27863252) Refractive error ( 32231278) Schizophrenia ( 23974872 25056061 29483656)
Interacting Genes		34 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36	8 interacting genes: ECSIT EXOSC6 HSPB2 KRAS LIG4 STAT3 UBE3A XRN1
Entrez ID		118460	51079
HPRD ID		12107	09452
Ensembl ID		ENSG00000223496	ENSG00000186010
Uniprot IDs		Q5RKV6	Q9P0J0
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8N 9G8O 9G8P	5XTB 5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Exosome (RNase Complex) RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance MRNA Metabolic Process Cytoplasmic Exosome (RNase Complex) Nucleobase-containing Compound Catabolic Process Nucleolar Exosome (RNase Complex) Nuclear RNA Surveillance RNA Surveillance RNA Exonuclease Activity RRNA Catabolic Process U4 SnRNA 3'-end Processing RNA Binding RNA Metabolic Process SnRNA Metabolic Process 3'-5'-RNA Exonuclease Activity Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Processing Macromolecule Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing RRNA 3'-end Processing TRNA Decay MRNA 3'-UTR AU-rich Region Binding RRNA Metabolic Process SnRNA Processing Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process RRNA Processing Catabolic Process Macromolecule Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Negative Regulation Of Gene Expression U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Histone MRNA Catabolic Process Sno(s)RNA Metabolic Process CUT Catabolic Process Histone MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA Binding Nucleolus	Nuclear MRNA Surveillance RRNA Catabolic Process Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Somatic Recombination Of Immunoglobulin Gene Segments Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins RNA Surveillance Nuclear RNA Surveillance Response To Lipid B Cell Activation Involved In Immune Response Somatic Stem Cell Population Maintenance Establishment Of Integrated Proviral Latency Sperm Entry Positive Regulation Of Golgi Lumen Acidification Cellular Response To Puromycin Cellular Response To Cycloheximide Neuron Apoptotic Process GMP Binding Forebrain Astrocyte Development Modulation Of Chemical Synaptic Transmission DNA Ligase (ATP) Activity Stem Cell Population Maintenance DNA Ligase IV Complex Establishment Of Viral Latency Lymphocyte Activation Involved In Immune Response DNA Ligase Activity Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Golgi Lumen Acidification Nuclear-transcribed MRNA Catabolic Process Maintenance Of Cell Number Somatic Muscle Development Cytosol Response To Isolation Stress Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination DN2 Thymocyte Differentiation RNA Sequestering Activity 5'-3' RNA Exonuclease Activity MRNA Catabolic Process Positive Regulation Of Developmental Process Response To Hormone Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Postsynapse To Nucleus Signaling Pathway MRNA Metabolic Process
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