DDX3Y and SHBG

Number of citations of the paper that reports this interaction (PubMedID 15862967)
0

Data Source:
HPRD (two hybrid)

		DDX3Y	SHBG
Description		DEAD-box helicase 3 Y-linked	sex hormone binding globulin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane P Granule	Extracellular Region Extracellular Exosome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Steroid Binding Androgen Binding Protein Binding Lipid Binding
	Biological Process	Gamete Generation Negative Regulation Of Gene Expression Cell Differentiation
Pathways
Drugs			Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate
Diseases
GWAS		Autism ( 32996047)	A body shape index ( 34021172) Androgen levels ( 22936694) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Estradiol levels ( 34255042) Glycated hemoglobin levels ( 34059833) Heel bone mineral density ( 30598549) Hormone measurements ( 24049095) Medication use (calcium channel blockers) ( 31015401) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 27863252) Refractive error ( 32231278) Sex hormone levels ( 26014426) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		23 interacting genes: CCR1 MIR106A MIR106B MIR107 MIR128-2 MIR143 MIR15B MIR18B MIR19B2 MIR20A MIR25 MIR31 MIR34A MIR363 MIR7-1 MIR7-2 MIR98 MIRLET7B MIRLET7D MIRLET7F1 MIRLET7G NPHP3 SHBG	62 interacting genes: A2M ACP3 ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5F1A AZGP1 CD177 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HDHD5 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SPMIP6 SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		8653	6462
HPRD ID		02452	01646
Ensembl ID		ENSG00000067048	ENSG00000129214
Uniprot IDs		O15523	B0FWH2 B0FWH8 I3L145 P04278
PDB IDs			1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW 6PYA 6PYB 6PYF 6ULB
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cytokine Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Space Negative Regulation Of Developmental Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Regulation Of Vasculature Development Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Tissue Remodeling Regulation Of Developmental Process Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway MRNA Destabilization Regulation Of Endothelial Cell Migration RNA Destabilization Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Multicellular Organismal Development Negative Regulation Of Glycoprotein Biosynthetic Process Regulation Of Translation Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development	Extracellular Exosome Protease Binding Cell-cell Junction Fructose Biosynthetic Process Detoxification Of Copper Ion Extracellular Space Glucose 6-phosphate:phosphate Antiporter Activity Cellular Response To Cadmium Ion Lamellipodium Cellular Response To Zinc Ion Cellular Response To Copper Ion Mesenchyme Migration Glucose-6-phosphate Transport Negative Regulation Of Cardiac Muscle Contraction Intracellular Zinc Ion Homeostasis Prostaglandin Metabolic Process Prostanoid Metabolic Process Response To Copper Ion Rough Endoplasmic Reticulum Hexose Metabolic Process Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Striated Muscle Contraction Response To Cadmium Ion Cell-cell Junction Organization Caveola Assembly Carbohydrate Metabolic Process Monosaccharide Metabolic Process Plasma Membrane Raft Assembly Response To Zinc Ion
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