SHBG and ACP3

Number of citations of the paper that reports this interaction (PubMedID 15862967)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SHBG	ACP3
Description		sex hormone binding globulin	acid phosphatase 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Lysosomal Membrane Multivesicular Body Cytosol Plasma Membrane Vesicle Membrane Membrane Secretory Granule Filopodium Golgi Cisterna Azurophil Granule Membrane Apical Part Of Cell Extracellular Exosome
	Molecular Function	Steroid Binding Androgen Binding Protein Binding Lipid Binding	Acid Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding 5'-nucleotidase Activity Hydrolase Activity Phosphatase Activity Choline Binding Thiamine Phosphate Phosphatase Activity Identical Protein Binding Protein Homodimerization Activity Lysophosphatidic Acid Phosphatase Activity Molecular Adaptor Activity
	Biological Process		Purine Nucleobase Metabolic Process Lipid Metabolic Process Thiamine Metabolic Process Nucleotide Metabolic Process Adenosine Metabolic Process Regulation Of Sensory Perception Of Pain Positive Regulation Of Adenosine Receptor Signaling Pathway
Pathways			Neutrophil degranulation
Drugs		Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate	(2R,3R)-2,3-Dihydroxy-4-oxo-4-(propylamino)butanoic acid Alpha-Benzyl-Aminobenzyl-Phosphonic Acid Sipuleucel-T
Diseases
GWAS		A body shape index ( 34021172) Androgen levels ( 22936694) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Estradiol levels ( 34255042) Glycated hemoglobin levels ( 34059833) Heel bone mineral density ( 30598549) Hormone measurements ( 24049095) Medication use (calcium channel blockers) ( 31015401) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 27863252) Refractive error ( 32231278) Sex hormone levels ( 26014426) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		62 interacting genes: A2M ACP3 ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5F1A AZGP1 CD177 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HDHD5 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SPMIP6 SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A	3 interacting genes: EPHB1 ERBB2 SHBG
Entrez ID		6462	55
HPRD ID		01646	01378
Ensembl ID		ENSG00000129214	ENSG00000014257
Uniprot IDs		B0FWH2 B0FWH8 I3L145 P04278	P15309
PDB IDs		1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW 6PYA 6PYB 6PYF 6ULB	1CVI 1ND5 1ND6 2HPA 2L3H 2L77 2L79 2MG0 3PPD 7ZZV 8XJ4
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Protease Binding Cell-cell Junction Fructose Biosynthetic Process Detoxification Of Copper Ion Extracellular Space Glucose 6-phosphate:phosphate Antiporter Activity Cellular Response To Cadmium Ion Lamellipodium Cellular Response To Zinc Ion Cellular Response To Copper Ion Mesenchyme Migration Glucose-6-phosphate Transport Negative Regulation Of Cardiac Muscle Contraction Intracellular Zinc Ion Homeostasis Prostaglandin Metabolic Process Prostanoid Metabolic Process Response To Copper Ion Rough Endoplasmic Reticulum Hexose Metabolic Process Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Striated Muscle Contraction Response To Cadmium Ion Cell-cell Junction Organization Caveola Assembly Carbohydrate Metabolic Process Monosaccharide Metabolic Process Plasma Membrane Raft Assembly Response To Zinc Ion	Transmembrane Receptor Protein Tyrosine Kinase Activity Optic Nerve Morphogenesis Negative Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Regulation Of ERK1 And ERK2 Cascade Neuron Projection Guidance Hindbrain Tangential Cell Migration Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Axon Guidance Protein Tyrosine Kinase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Androgen Binding Skeletal Muscle Satellite Cell Activation Negative Regulation Of Immature T Cell Proliferation Negative Regulation Of Skeletal Muscle Cell Differentiation Protein Phosphorylation Phosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB4 Signaling Pathway Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Neuron Projection Development Cell Migration In Hindbrain Axon Guidance Receptor Activity Immunological Synapse Formation Cranial Nerve Morphogenesis Dendritic Spine Development Protein Kinase Activity Regulation Of Skeletal Muscle Satellite Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Activity Negative Regulation Of T Cell Differentiation In Thymus Semaphorin Receptor Complex Regulation Of Immature T Cell Proliferation In Thymus Filopodium Tip Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Dendritic Spine Morphogenesis Nervous System Development Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Enzyme-linked Receptor Protein Signaling Pathway Detection Of Temperature Stimulus Central Nervous System Projection Neuron Axonogenesis
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