PTCH2 and DHH

Number of citations of the paper that reports this interaction (PubMedID 9811851)
39

Data Source:
HPRD (in vivo)

		PTCH2	DHH
Description		patched 2	desert hedgehog signaling molecule
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Smoothened Binding Hedgehog Receptor Activity Hedgehog Family Protein Binding	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Zinc Ion Binding Transferase Activity Hydrolase Activity Metal Ion Binding Cholesterol-protein Transferase Activity
	Biological Process	Regulation Of Cell Growth Cell Fate Determination Epidermis Development Epidermal Cell Fate Specification Hair Cycle Skin Development Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway	Osteoblast Differentiation Cell Fate Specification Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Spermatid Development Regulation Of Gene Expression Protein Autoprocessing Male Sex Determination Response To Estradiol Leydig Cell Differentiation Myelination Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Regulation Of Steroid Biosynthetic Process Self Proteolysis
Pathways		Class B/2 (Secretin family receptors)	Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V doesn't palmitoylate Hh-Np Transcriptional regulation of testis differentiation
Drugs
Diseases		Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome	46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Intraocular pressure ( 30591961)	Bipolar disorder ( 31043756) Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Lumbar spine bone mineral density ( 22504420)
Interacting Genes		4 interacting genes: DHH IHH SHH SMO	3 interacting genes: HHIP PTCH1 PTCH2
Entrez ID		8643	50846
HPRD ID		04722	05664
Ensembl ID		ENSG00000117425	ENSG00000139549
Uniprot IDs		Q9Y6C5	O43323
PDB IDs			2WFQ 2WFR 2WG3 3N1G 3N1Q
Enriched GO Terms of Interacting Partners?		Patched Binding Cholesterol-protein Transferase Activity Positive Regulation Of Smoothened Signaling Pathway Smoothened Signaling Pathway Self Proteolysis Regulation Of Smoothened Signaling Pathway Cell Fate Specification Somite Development Smooth Muscle Tissue Development Protein Autoprocessing Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Intein-mediated Protein Splicing Heart Looping Embryonic Heart Tube Morphogenesis Epithelial-mesenchymal Cell Signaling Epithelial Tube Morphogenesis Positive Regulation Of T Cell Differentiation In Thymus Spinal Cord Dorsal/ventral Patterning Cell-cell Signaling Determination Of Left/right Asymmetry In Lateral Mesoderm Negative Regulation Of T Cell Differentiation In Thymus Osteoblast Differentiation Signaling Cell Communication Thalamus Development Regulation Of Immature T Cell Proliferation In Thymus Muscle Tissue Development Dorsal/ventral Neural Tube Patterning Protein Processing Embryonic Digestive Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Cell Development Epithelium Development Regulation Of T Cell Differentiation In Thymus Pancreas Development Positive Regulation Of Neuroblast Proliferation Negative Regulation Of Alpha-beta T Cell Differentiation Hair Follicle Morphogenesis Tube Morphogenesis Branching Involved In Blood Vessel Morphogenesis Dopaminergic Neuron Differentiation Protein Maturation Morphogenesis Of An Epithelium Neuron Fate Commitment Positive Regulation Of Protein Import Into Nucleus Golgi Apparatus Hair Follicle Development Regulation Of Neuroblast Proliferation Regulation Of Epithelial Cell Proliferation	Hedgehog Family Protein Binding Negative Regulation Of Smoothened Signaling Pathway Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Regulation Of Smoothened Signaling Pathway Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Cell Fate Determination Ciliary Membrane Positive Regulation Of Epithelial Cell Differentiation Regulation Of Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Regulation Of Epidermis Development Cell Fate Specification Neural Plate Axis Specification Branching Morphogenesis Of An Epithelial Tube Epidermis Development Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Epithelial Cell Differentiation Response To Chlorate Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regionalization Tube Morphogenesis Morphogenesis Of An Epithelium Cell Proliferation Involved In Metanephros Development Patched Binding Mammary Gland Duct Morphogenesis Neural Tube Patterning Dendritic Growth Cone Pattern Specification Process Neural Tube Formation Metanephric Collecting Duct Development Tissue Morphogenesis Cell Proliferation Involved In Kidney Development Dorsal/ventral Neural Tube Patterning Negative Regulation Of Multicellular Organism Growth Collecting Duct Development Commissural Neuron Axon Guidance Hair Cycle Somite Development Prostate Gland Development Animal Organ Morphogenesis Negative Regulation Of Cell Division Cellular Response To Cholesterol Mammary Gland Epithelial Cell Differentiation Pharyngeal System Development
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