PTCH2

Description		patched 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Smoothened Binding Hedgehog Receptor Activity Hedgehog Family Protein Binding
	Biological Process	Regulation Of Cell Growth Cell Fate Determination Epidermis Development Epidermal Cell Fate Specification Hair Cycle Skin Development Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway
Pathways		Class B/2 (Secretin family receptors)
Drugs
Diseases		Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome
GWAS		Intraocular pressure ( 30591961)
Novel Interacting Genes		4 novel interacting genes: DHH IHH SHH SMO
Interacting Genes		4 interacting genes: DHH IHH SHH SMO
Entrez ID		8643
HPRD ID		04722
Ensembl ID		ENSG00000117425
Uniprot IDs		Q9Y6C5
PDB IDs
Enriched GO Terms of Interacting Partners?		Patched Binding Cholesterol-protein Transferase Activity Positive Regulation Of Smoothened Signaling Pathway Smoothened Signaling Pathway Self Proteolysis Regulation Of Smoothened Signaling Pathway Cell Fate Specification Somite Development Smooth Muscle Tissue Development Protein Autoprocessing Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Intein-mediated Protein Splicing Heart Looping Embryonic Heart Tube Morphogenesis Epithelial-mesenchymal Cell Signaling Epithelial Tube Morphogenesis Positive Regulation Of T Cell Differentiation In Thymus Spinal Cord Dorsal/ventral Patterning Cell-cell Signaling Determination Of Left/right Asymmetry In Lateral Mesoderm Negative Regulation Of T Cell Differentiation In Thymus Osteoblast Differentiation Signaling Cell Communication Thalamus Development Regulation Of Immature T Cell Proliferation In Thymus Muscle Tissue Development Dorsal/ventral Neural Tube Patterning Protein Processing Embryonic Digestive Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Cell Development Epithelium Development Regulation Of T Cell Differentiation In Thymus Pancreas Development Positive Regulation Of Neuroblast Proliferation Negative Regulation Of Alpha-beta T Cell Differentiation Hair Follicle Morphogenesis Tube Morphogenesis Branching Involved In Blood Vessel Morphogenesis Dopaminergic Neuron Differentiation Protein Maturation Morphogenesis Of An Epithelium Neuron Fate Commitment Positive Regulation Of Protein Import Into Nucleus Golgi Apparatus Hair Follicle Development Regulation Of Neuroblast Proliferation Regulation Of Epithelial Cell Proliferation
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