RGS20 and OSTM1

Number of citations of the paper that reports this interaction (PubMedID 12826607)
47

Data Source:
HPRD (two hybrid)

		RGS20	OSTM1
Description		regulator of G protein signaling 20	osteoclastogenesis associated transmembrane protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Trans-Golgi Network Plasma Membrane Membrane	Lysosome Lysosomal Membrane Cytosol Membrane Chloride Channel Complex
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction	Osteoclast Differentiation Transepithelial Chloride Transport
Pathways		G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events	Stimuli-sensing channels
Drugs
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Chronic obstructive pulmonary disease ( 32222710) Serum uric acid levels ( 29559957) Urinary albumin-to-creatinine ratio ( 26631737)	Major depressive disorder ( 29187746) Psoriasis ( 31376382)
Interacting Genes		58 interacting genes: ABHD17A ADRB2 ALPP AQP1 CATSPER1 COL8A1 CRCT1 CREB5 FASLG GLRX3 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HOXA1 HRG HSPD1 INS KIF1A KLHL38 KRTAP4-2 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 MAPKBP1 NECTIN2 NECTIN3 NEK8 NUFIP2 OSTM1 OTX1 PTGER3 PTPMT1 RANBP3 STMN2 TBC1D16 VASN	7 interacting genes: CFTR CLCN7 GPSM1 LIG4 RGS17 RGS19 RGS20
Entrez ID		8601	28962
HPRD ID		06225	09628
Ensembl ID		ENSG00000147509	ENSG00000081087
Uniprot IDs		B3KSW4 H9NIM5 O76081	A0A8V8TNX7 A0A8V8TPT7 Q86WC4
PDB IDs			7BXU 7CQ5 7CQ6 7CQ7 7JM7 8HVT
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Tissue Development Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Intermediate Filament Heterotrimeric G-protein Complex Identical Protein Binding Protein Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion Positive Regulation Of Immune Response To Tumor Cell G Protein-coupled Serotonin Receptor Signaling Pathway Neuronal Dense Core Vesicle Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity G Protein-coupled Receptor Binding Negative Regulation Of Protein Secretion Regulation Of Response To Tumor Cell Negative Regulation Of Secretion By Cell Negative Regulation Of Insulin Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Peptide Secretion Hippocampal Mossy Fiber To CA3 Synapse Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Protein Transport Negative Regulation Of Protein Localization Developmental Process Adhesion Of Symbiont To Host	Chloride Transmembrane Transporter Activity Transepithelial Transport Chloride Channel Complex Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Integrated Proviral Latency GTPase Activity Inorganic Anion Transport Monoatomic Anion Transmembrane Transport Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Chloride Transmembrane Transport Inorganic Anion Transmembrane Transport Chloride Transport Positive Regulation Of Monoatomic Anion Transport Monoatomic Anion Transport Chloride:proton Antiporter Activity DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Transepithelial Water Transport Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Tooth Mineralization Nucleotide-excision Repair, DNA Gap Filling Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization DNA-dependent Protein Kinase-DNA Ligase 4 Complex G Protein-coupled Receptor Signaling Pathway Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Transepithelial Chloride Transport Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair GTPase Activator Activity Lymphoid Progenitor Cell Differentiation AMP Binding Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport
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