OSTM1

Description		osteoclastogenesis associated transmembrane protein 1
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Membrane Chloride Channel Complex
	Molecular Function	Protein Binding
	Biological Process	Osteoclast Differentiation Transepithelial Chloride Transport
Pathways		Stimuli-sensing channels
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Major depressive disorder ( 29187746) Psoriasis ( 31376382)
Novel Interacting Genes		7 novel interacting genes: CFTR CLCN7 GPSM1 LIG4 RGS17 RGS19 RGS20
Interacting Genes		7 interacting genes: CFTR CLCN7 GPSM1 LIG4 RGS17 RGS19 RGS20
Entrez ID		28962
HPRD ID		09628
Ensembl ID		ENSG00000081087
Uniprot IDs		A0A8V8TNX7 A0A8V8TPT7 Q86WC4
PDB IDs		7BXU 7CQ5 7CQ6 7CQ7 7JM7 8HVT
Enriched GO Terms of Interacting Partners?		Chloride Transmembrane Transporter Activity Transepithelial Transport Chloride Channel Complex Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Establishment Of Integrated Proviral Latency GTPase Activity Inorganic Anion Transport Monoatomic Anion Transmembrane Transport Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Chloride Transmembrane Transport Inorganic Anion Transmembrane Transport Chloride Transport Positive Regulation Of Monoatomic Anion Transport Monoatomic Anion Transport Chloride:proton Antiporter Activity DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Transepithelial Water Transport Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Tooth Mineralization Nucleotide-excision Repair, DNA Gap Filling Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization DNA-dependent Protein Kinase-DNA Ligase 4 Complex G Protein-coupled Receptor Signaling Pathway Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Transepithelial Chloride Transport Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair GTPase Activator Activity Lymphoid Progenitor Cell Differentiation AMP Binding Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport
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