LY6D and TMEM86B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LY6D	TMEM86B
Description		lymphocyte antigen 6 family member D	transmembrane protein 86B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Side Of Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Hydrolase Activity Ether Hydrolase Activity Identical Protein Binding Alkenylglycerophosphocholine Hydrolase Activity D-lysine 5,6-aminomutase Activity
	Biological Process	Cell Adhesion Lymphocyte Differentiation Response To Stilbenoid	Lipid Metabolic Process Phosphatidylcholine Acyl-chain Remodeling Ether Lipid Metabolic Process
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Acyl chain remodelling of PC
Drugs
Diseases
GWAS			Mean reticulocyte volume ( 32888494) Phosphatidylethanolamine-ether levels ( 31551469) Serum metabolite levels ( 33031748) Systemic lupus erythematosus ( 28714469 33536424)
Interacting Genes		7 interacting genes: ABCB11 AQP6 ARFIP2 ELOVL4 PKIB TMEM31 TMEM86B	106 interacting genes: AQP6 ARL13B ARL6IP6 ASGR2 BCL2L13 BIK BMP10 C2CD2L CCDC167 CCDC34 CCL4 CD53 CD79A CLRN1 CYB5B DHRSX DNAJC30 EBP ERGIC3 ERP29 EVI2B F11R FAM209A FAXDC2 FFAR2 FKBP7 FXYD6 GJA1 GJA4 GJA8 GOLM1 GPR37L1 GPX8 GUCA2A HIBADH HSD17B13 IER3IP1 IFITM3 KIR2DL3 LAPTM4B LIME1 LSS LY6D MARCHF2 MFF MGST3 MMGT1 MS4A14 MSMO1 MUC1 NDUFAF1 NEMP1 NINJ2 ORMDL2 OTULINL PEX11G PGRMC2 PIGF PLN PSCA PTPN1 PTPN9 RHBDD1 RHOT2 RPRM RTP2 SEC22B SERINC2 SFRP1 SFT2D1 SFXN5 SLC10A6 SLC29A2 SLC35G2 SLC39A9 SMIM1 SNORC SSMEM1 STOM STX12 STX6 STX8 TEX29 THAP4 THBD TIMM23 TMEM106A TMEM107 TMEM120A TMEM14A TMEM14C TMEM203 TMEM237 TMEM248 TMEM52B TMEM60 TMPRSS2 TMX2 TREX1 TSNARE1 USE1 VAMP2 VAMP3 VAMP5 VAPA ZDHHC22
Entrez ID		8581	255043
HPRD ID		09370	14540
Ensembl ID		ENSG00000167656	ENSG00000180089
Uniprot IDs		Q14210	Q8N661
PDB IDs
Enriched GO Terms of Interacting Partners?		PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Canalicular Bile Acid Transmembrane Transporter Activity Positive Regulation Of Bile Acid Secretion Canalicular Bile Acid Transport D-lysine 5,6-aminomutase Activity Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Intracellular Canaliculus Regulation Of Bile Acid Secretion ABC-type Bile Acid Transporter Activity Membrane Curvature Sensor Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Intercellular Canaliculus Monoatomic Anion Channel Activity Renal Water Transport Fatty Acid Elongation, Saturated Fatty Acid Ammonium Transmembrane Transport Ammonium Channel Activity CAMP-dependent Protein Kinase Inhibitor Activity Carboxylic Acid Biosynthetic Process G Protein-coupled Photoreceptor Activity Bile Acid Transmembrane Transporter Activity Regulation Of Bile Acid Metabolic Process Water Channel Activity Carbon Dioxide Transport Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Fatty Acid Metabolic Process Xenobiotic Export From Cell ABC-type Xenobiotic Transporter Activity Xenobiotic Transmembrane Transport Phosphatidylcholine Acyl-chain Remodeling Phospholipid Homeostasis Regulation Of Fatty Acid Beta-oxidation Protein Localization To Phagophore Assembly Site Lipid Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Bile Acid And Bile Salt Transport GTP-dependent Protein Binding Ether Lipid Metabolic Process	Membrane SNAP Receptor Activity Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex Protein Binding Membrane Fusion Mitochondrial Membrane Endomembrane System Plasma Membrane Organelle Localization By Membrane Tethering Membrane Organization Cellular Localization Vesicle Membrane Docking Vesicle Fusion Vesicle Docking Organelle Membrane Fusion SNARE Binding Golgi Vesicle Transport C-4 Methylsterol Oxidase Activity Sterol Biosynthetic Process Vesicle Organization Organelle Fusion Connexin Complex B Cell Receptor Complex Gap Junction Channel Activity Nuclear Inner Membrane Localization Within Membrane Gap Junction
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