SYTL1 and NCF1

Number of citations of the paper that reports this interaction (PubMedID 11278853)
0

Data Source:
BioGRID (pull down)

		SYTL1	NCF1
Description		synaptotagmin like 1	neutrophil cytosolic factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Microvillus Membrane Melanosome Extracellular Exosome Exocytic Vesicle	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	Protein Binding Small GTPase Binding Neurexin Family Protein Binding	Protein Binding Lipid Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Intracellular Protein Transport Exocytosis	Response To Yeast Leukocyte Mediated Cytotoxicity Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Inflammatory Response Cellular Defense Response Response To Bacterium Superoxide Anion Generation Defense Response To Bacterium Innate Immune Response Respiratory Burst Hydrogen Peroxide Biosynthetic Process Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Defense Response To Fungus Regulation Of Respiratory Burst Involved In Inflammatory Response Neutrophil-mediated Killing Of Gram-positive Bacterium Neutrophil-mediated Killing Of Fungus Cellular Response To Glucose Stimulus Cellular Response To Testosterone Stimulus Reactive Oxygen Species Metabolic Process Reactive Oxygen Species Biosynthetic Process
Pathways		TBC/RABGAPs	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs			Dextromethorphan
Diseases			Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS			Systemic lupus erythematosus ( 33493351)
Interacting Genes		7 interacting genes: AKT1 NCF1 NCF2 NRXN1 RAB27A RAB27B RAB8A	29 interacting genes: ACTB CEBPA CSNK2B FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN RB1 SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		84958	653361
HPRD ID		12156
Ensembl ID		ENSG00000142765	ENSG00000158517
Uniprot IDs		Q8IYJ3	P14598
PDB IDs			1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP 7YXW 8WEJ
Enriched GO Terms of Interacting Partners?		Myosin V Binding Establishment Of Protein Localization Protein Localization To Synapse Phagolysosome GDP Binding Protein Localization To Cell Junction Superoxide-generating NADPH Oxidase Activator Activity Superoxide-generating NAD(P)H Oxidase Activity Secretion By Cell NADPH Oxidase Complex Trans-Golgi Network Transport Vesicle Vesicle-mediated Transport Secretion Localization Within Membrane Respiratory Burst Superoxide Anion Generation Phosphatidylinositol-3,4-bisphosphate Binding Exocytosis Multivesicular Body Membrane Exocytic Vesicle Establishment Of Protein Localization To Membrane Cellular Localization Establishment Of Localization In Cell Superoxide Metabolic Process Multivesicular Body Sorting Pathway Receptor Localization To Synapse Cellular Defense Response Protein Localization To Membrane Intracellular Protein Localization GTPase Activity Establishment Of Protein Localization To Plasma Membrane Electron Transfer Activity Protein Localization To Cilium Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Calcium Ion Regulation Of TRNA Methylation GTP Binding Neuronal Cell Body Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway G Protein Activity Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Positive Regulation Of Protein Localization To Cell Periphery Protein Transport Positive Regulation Of Exocytosis Positive Regulation Of Protein Localization To Membrane Vesicle-mediated Transport In Synapse	Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Enzyme Binding Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Immune System Process Cytosol Protein Phosphorylation Protein Domain Specific Binding Regulation Of Protein Metabolic Process Phosphorylation Maltose Metabolic Process NADPH Oxidase Complex Histone H3T6 Kinase Activity Positive Regulation Of Immune System Process Protein Serine/threonine Kinase Activity Regulation Of Hemopoiesis Regulation Of G1/S Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation Regulation Of Cell Activation Alpha-1,4-glucosidase Activity Superoxide Anion Generation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Positive Regulation Of Leukocyte Differentiation Alpha-glucosidase Activity Phagolysosome Regulation Of Proteasomal Protein Catabolic Process Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Rb-E2F Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Regulation Of Proteolysis Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transport Regulation Of Cell Development Superoxide Metabolic Process Plasma Membrane Extracellular Exosome Response To Hormone Nuclear Matrix Regulation Of Multicellular Organismal Development
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