NCF1 and NCF4

Number of citations of the paper that reports this interaction (PubMedID 11258927)
0

Data Source:
BioGRID (pull down, two hybrid)

		NCF1	NCF4
Description		neutrophil cytosolic factor 1	neutrophil cytosolic factor 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body	Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Protein Binding Lipid Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding	Protein Binding Lipid Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Response To Yeast Leukocyte Mediated Cytotoxicity Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Inflammatory Response Cellular Defense Response Response To Bacterium Superoxide Anion Generation Defense Response To Bacterium Innate Immune Response Respiratory Burst Hydrogen Peroxide Biosynthetic Process Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Defense Response To Fungus Regulation Of Respiratory Burst Involved In Inflammatory Response Neutrophil-mediated Killing Of Gram-positive Bacterium Neutrophil-mediated Killing Of Fungus Cellular Response To Glucose Stimulus Cellular Response To Testosterone Stimulus Reactive Oxygen Species Metabolic Process Reactive Oxygen Species Biosynthetic Process	Phagocytosis Superoxide Anion Generation Respiratory Burst
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Dextromethorphan	Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Systemic lupus erythematosus ( 33493351)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Atopic dermatitis ( 22197932) Crohn's disease ( 28067908) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Multiple sclerosis ( 24076602 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		29 interacting genes: ACTB CEBPA CSNK2B FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN RB1 SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9	11 interacting genes: CORO1A CRYAA CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6
Entrez ID		653361	4689
HPRD ID			03289
Ensembl ID		ENSG00000158517	ENSG00000100365
Uniprot IDs		P14598	A0A494BZS1 Q15080
PDB IDs		1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP 7YXW 8WEJ	1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Enzyme Binding Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Immune System Process Cytosol Protein Phosphorylation Protein Domain Specific Binding Regulation Of Protein Metabolic Process Phosphorylation Maltose Metabolic Process NADPH Oxidase Complex Histone H3T6 Kinase Activity Positive Regulation Of Immune System Process Protein Serine/threonine Kinase Activity Regulation Of Hemopoiesis Regulation Of G1/S Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation Regulation Of Cell Activation Alpha-1,4-glucosidase Activity Superoxide Anion Generation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Positive Regulation Of Leukocyte Differentiation Alpha-glucosidase Activity Phagolysosome Regulation Of Proteasomal Protein Catabolic Process Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Rb-E2F Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Regulation Of Proteolysis Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transport Regulation Of Cell Development Superoxide Metabolic Process Plasma Membrane Extracellular Exosome Response To Hormone Nuclear Matrix Regulation Of Multicellular Organismal Development	Superoxide-generating NAD(P)H Oxidase Activity NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide Metabolic Process Innate Immune Response Hydrogen Peroxide Biosynthetic Process Response To Other Organism Electron Transfer Activity Immune Response Defense Response To Symbiont Defense Response To Other Organism Immune System Process Response To Radiation Reactive Oxygen Species Biosynthetic Process Response To External Biotic Stimulus Defense Response Response To Angiotensin Cellular Response To L-glutamine Phagolysosome DNA-dependent Protein Kinase Complex Response To Gamma Radiation DNA-dependent Protein Kinase-DNA Ligase 4 Complex Response To Stress Nonhomologous End Joining Complex Regulation Of Immune System Process Superoxide-generating NADPH Oxidase Activator Activity Phagocytic Vesicle Membrane Regulation Of Intracellular Transport Response To Peptide Hormone Immunological Synapse Formation Cellular Response To Angiotensin Lymphocyte Proliferation Response To Aldosterone Cytoplasm Mononuclear Cell Proliferation Perinuclear Endoplasmic Reticulum Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Leukocyte Proliferation Peptidyl-threonine Phosphorylation Response To Ionizing Radiation Regulation Of Defense Response Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Oxygen-containing Compound Regulation Of Innate Immune Response Cellular Response To Gamma Radiation Lymphocyte Activation
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