TMEM25 and NLRX1

		TMEM25	NLRX1
Description		transmembrane protein 25	NLR family member X1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Endosome Late Endosome Plasma Membrane Membrane	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding ATP Binding
	Biological Process	Regulation Of Protein Stability Negative Regulation Of Excitatory Postsynaptic Potential	Immune System Process Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Regulation of NF-kappa B signaling
Drugs
Diseases
GWAS			Mean reticulocyte volume ( 32888494)
Interacting Genes		4 interacting genes: ATXN1L GLRX3 NLRX1 RABGGTB	9 interacting genes: ABCG4 BUD13 C1QTNF5 IFT46 NHERF4 SARM1 SCN3B TMEM25 TMPRSS4
Entrez ID		84866	79671
HPRD ID		11635	17640
Ensembl ID		ENSG00000149582	ENSG00000160703
Uniprot IDs		B7Z1M8 E9PKP3 Q86YD3	A0A9L9PX86 Q86UT6
PDB IDs			3UN9
Enriched GO Terms of Interacting Partners?		Protein Geranylgeranylation Rab-protein Geranylgeranyltransferase Complex Protein Prenyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Prenyltransferase Activity Protein Prenylation [2Fe-2S] Cluster Assembly Negative Regulation Of RIG-I Signaling Pathway POZ Domain Binding Positive Regulation Of Hematopoietic Stem Cell Proliferation Iron-sulfur Cluster Assembly Complex Negative Regulation Of Macrophage Cytokine Production	NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Negative Regulation Of Growth Rate Guanylate Cyclase Inhibitor Activity RES Complex Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process ABC-type Sterol Transporter Activity
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