NLRX1 and IFT46

		NLRX1	IFT46
Description		NLR family member X1	intraflagellar transport 46
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane	Cytoplasm Centrosome Microtubule Organizing Center Cytoskeleton Cilium Intraciliary Transport Particle B Motile Cilium Ciliary Basal Body Cell Projection Ciliary Tip Plasma Membrane Bounded Cell Projection
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding	Protein Binding
	Biological Process	Immune System Process Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response	Smoothened Signaling Pathway Intraciliary Anterograde Transport Intraciliary Transport Protein Stabilization Cilium Assembly
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Regulation of NF-kappa B signaling	Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)	Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		9 interacting genes: ABCG4 BUD13 C1QTNF5 IFT46 NHERF4 SARM1 SCN3B TMEM25 TMPRSS4	4 interacting genes: FBXL17 MTDH NLRX1 UBXN10
Entrez ID		79671	56912
HPRD ID		17640	07967
Ensembl ID		ENSG00000160703	ENSG00000118096
Uniprot IDs		A0A9L9PX86 Q86UT6	Q9NQC8
PDB IDs		3UN9
Enriched GO Terms of Interacting Partners?		NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Negative Regulation Of Growth Rate Guanylate Cyclase Inhibitor Activity RES Complex Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process ABC-type Sterol Transporter Activity
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