PCGF1 and CD244

		PCGF1	CD244
Description		polycomb group ring finger 1	CD244 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Plasma Membrane External Side Of Plasma Membrane Membrane Membrane Raft
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding	Protein Binding Signaling Receptor Activity MHC Class I Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription	Adaptive Immune Response Natural Killer Cell Activation Involved In Immune Response Immune System Process Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Innate Immune Response Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Granzyme B Production
Pathways			Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS			Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: CALCOCO2 CBX7 CD244 FCHO1 H2AC4 MUC7 RNF125 RNF2 TRIM55 UBE2D3 UBE2U	11 interacting genes: ACO2 ARHGEF7 CD247 CD48 LAT OLFML2B PCGF1 PDGFRA SH2D1A SH2D1B TOMM40L
Entrez ID		84759	51744
HPRD ID		11404	16121
Ensembl ID		ENSG00000115289	ENSG00000122223
Uniprot IDs		Q9BSM1	Q9BZW8
PDB IDs		4HPL 4HPM 5JH5 8HCU
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Polyubiquitination Ubiquitin Protein Ligase Activity PRC1 Complex Protein Modification By Small Protein Conjugation Post-translational Protein Modification PcG Protein Complex Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Positive Regulation Of Granzyme B Production	Cell Activation Leukocyte Activation Adaptive Immune Response Lymphocyte Activation Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response Immune Response Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Immunity Platelet-derived Growth Factor Alpha-receptor Activity Negative Regulation Of Microtubule Nucleation Aconitate Hydratase Activity Fc-gamma Receptor III Complex Gamma-delta T Cell Receptor Complex Immune Effector Process Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Platelet-derived Growth Factor Receptor-ligand Complex TCR Signalosome
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