GPT2 and HEATR3

		GPT2	HEATR3
Description		glutamic--pyruvic transaminase 2	HEAT repeat containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	L-alanine:2-oxoglutarate Aminotransferase Activity Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding	Unfolded Protein Binding
	Biological Process	2-oxoglutarate Metabolic Process L-alanine Metabolic Process L-alanine Catabolic Process	Protein Import Into Nucleus Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Erythrocyte Maturation
Pathways
Drugs		Pyridoxal phosphate Glutamic acid Alanine Phenelzine
Diseases
GWAS			Appendicular lean mass ( 33097823) Epilepsy ( 30531953) Esophageal cancer (squamous cell) ( 22960999) Glioblastoma ( 28346443) Glioma ( 28346443) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 28957414) Systemic lupus erythematosus ( 33272962) Testicular germ cell tumor ( 23666239 23666240 28604728 28604732) Uterine fibroids ( 31249589)
Interacting Genes		4 interacting genes: AKT1 APP HEATR3 OGT	3 interacting genes: AKT1 CEBPA GPT2
Entrez ID		84706	55027
HPRD ID		06307	07945
Ensembl ID		ENSG00000166123	ENSG00000155393
Uniprot IDs		Q8TD30	Q7Z4Q2
PDB IDs		3IHJ
Enriched GO Terms of Interacting Partners?		Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Proteolysis Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Synapse Organization Response To Nerve Growth Factor Negative Regulation Of Translational Initiation Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Proteolysis Regulation Of Small Molecule Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Translational Initiation Positive Regulation Of Nitric Oxide Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of Translation Regulation Of Glycolytic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of TORC1 Signaling Regulation Of Nitric Oxide Metabolic Process TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Regulation Of Lymphocyte Migration Negative Regulation Of Protein Ubiquitination Regulation Of ATP Metabolic Process Protein Localization To Organelle Regulation Of Phosphorus Metabolic Process TOR Signaling Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation Negative Regulation Of Post-translational Protein Modification Positive Regulation Of TOR Signaling Positive Regulation Of Lipid Biosynthetic Process Regulation Of TRNA Methylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Import Into Nucleus Cytoplasmic Translation Import Into Nucleus Positive Regulation Of Mitotic Cell Cycle Protein-containing Complex Positive Regulation Of Protein Localization To Endoplasmic Reticulum	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Fat Cell Differentiation Integrated Stress Response Signaling Kinase Binding Response To Tumor Necrosis Factor Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Fat Cell Differentiation Regulation Of TRNA Methylation Cellular Response To Tumor Necrosis Factor RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Carbohydrate Homeostasis Positive Regulation Of Protein Localization To Endoplasmic Reticulum Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Regulation Of Ubiquitin-dependent Protein Catabolic Process Embryonic Organ Development Mitochondrion Organization Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Protein Catabolic Process TRNA (guanine-N7)-methylation Response To Ketone TORC2 Complex Binding Cellular Response To Rapamycin Small Molecule Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Cellular Response To Metal Ion SREBP-SCAP Complex Retention In Endoplasmic Reticulum CHOP-C/EBP Complex Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex L-alanine Metabolic Process L-alanine Catabolic Process L-alanine:2-oxoglutarate Aminotransferase Activity Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Fatty Acid Beta-oxidation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex
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