DPY30 and ARFGEF1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DPY30	ARFGEF1
Description		dpy-30 histone methyltransferase complex regulatory subunit	ARF guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane Nuclear Matrix Small Nuclear Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Chromatin Organization Endosomal Transport Transcription Initiation-coupled Chromatin Remodeling	Protein Glycosylation Exocytosis Golgi Organization Endomembrane System Organization Protein Transport Negative Regulation Of Actin Filament Polymerization Neuron Projection Development Regulation Of ARF Protein Signal Transduction Negative Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Wound Healing Regulation Of Establishment Of Cell Polarity
Pathways		PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Drugs
Diseases
GWAS		Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	Chronic central serous retinopathy ( 30073298) Hearing function ( 25060954) Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19	6 interacting genes: ARFGEF2 CTNNB1 DPY30 FKBP2 LYN MYO9B
Entrez ID		84661	10565
HPRD ID		17434	09163
Ensembl ID		ENSG00000162961	ENSG00000066777
Uniprot IDs		Q9C005	Q9Y6D6
PDB IDs		3G36 4RIQ 4RT4 4RTA 6E2H 6PWV 7UD5	3LTL 5EE5 5J5C
Enriched GO Terms of Interacting Partners?		Set1C/COMPASS Complex Gonadal Mesoderm Development Histone Methyltransferase Complex Chromatin Remodeling Nucleosome Assembly Nucleosome Organization Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Chromatin Organization Mesoderm Development Mesenchyme Development MLL3/4 Complex Histone H3K4 Methyltransferase Activity Proteasome Accessory Complex Protein-DNA Complex Assembly Midbody Abscission Beta-catenin Binding Protein Kinase A Regulatory Subunit Binding Mitotic Cytokinetic Process 9+2 Motile Cilium Axoneme	Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Hemopoiesis Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Gliogenesis Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Intracellular Signal Transduction Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Timing Of Anagen Lamellipodium Fungiform Papilla Formation Negative Regulation Of Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transmembrane Transporter Binding Beta-catenin-TCF7L2 Complex Cellular Response To Indole-3-methanol Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Perinuclear Region Of Cytoplasm Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Central Nervous System Vasculogenesis Hemopoiesis Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Cell Cortex Cranial Ganglion Development Regulation Of Centriole-centriole Cohesion Adherens Junction Renal Outer Medulla Development Regulation Of Myeloid Leukocyte Differentiation Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Glial Cell-neuron Signaling Lung Induction Regulation Of Centromeric Sister Chromatid Cohesion Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Cell Morphogenesis Positive Regulation Of Branching Involved In Lung Morphogenesis
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