ARFGEF1 and ARFGEF2

Number of citations of the paper that reports this interaction (PubMedID 36652389)
40

Data Source:
BioGRID (cross-linking study)
HPRD (in vivo)

		ARFGEF1	ARFGEF2
Description		ARF guanine nucleotide exchange factor 1	ARF guanine nucleotide exchange factor 2
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane Nuclear Matrix Small Nuclear Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm	Golgi Membrane Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Axonemal Microtubule Membrane Dendrite Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Cell Projection Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding
	Biological Process	Protein Glycosylation Exocytosis Golgi Organization Endomembrane System Organization Protein Transport Negative Regulation Of Actin Filament Polymerization Neuron Projection Development Regulation Of ARF Protein Signal Transduction Negative Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Wound Healing Regulation Of Establishment Of Cell Polarity	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction
Pathways			Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases			Periventricular nodular heterotopia (PVNH)
GWAS		Chronic central serous retinopathy ( 30073298) Hearing function ( 25060954) Hip circumference adjusted for BMI ( 28552196)	Adult body size ( 32376654) Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		6 interacting genes: ARFGEF2 CTNNB1 DPY30 FKBP2 LYN MYO9B	12 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 LCOR PNPLA2 PRKAR1A PRKAR2A PRPF40A PTGIS SLC9A8
Entrez ID		10565	10564
HPRD ID		09163	09250
Ensembl ID		ENSG00000066777	ENSG00000124198
Uniprot IDs		Q9Y6D6	A0A7P0T7Z2 Q59FR3 Q86TH5 Q9Y6D5
PDB IDs		3LTL 5EE5 5J5C	3L8N 3SWV
Enriched GO Terms of Interacting Partners?		Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Hemopoiesis Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Gliogenesis Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Intracellular Signal Transduction Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Timing Of Anagen Lamellipodium Fungiform Papilla Formation Negative Regulation Of Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transmembrane Transporter Binding Beta-catenin-TCF7L2 Complex Cellular Response To Indole-3-methanol Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Perinuclear Region Of Cytoplasm Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Central Nervous System Vasculogenesis Hemopoiesis Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Cell Cortex Cranial Ganglion Development Regulation Of Centriole-centriole Cohesion Adherens Junction Renal Outer Medulla Development Regulation Of Myeloid Leukocyte Differentiation Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Glial Cell-neuron Signaling Lung Induction Regulation Of Centromeric Sister Chromatid Cohesion Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Cell Morphogenesis Positive Regulation Of Branching Involved In Lung Morphogenesis	Cellular Response To Histamine Response To Histamine GABA-A Receptor Activity GABA-gated Chloride Ion Channel Activity GABA-A Receptor Complex Gamma-aminobutyric Acid Signaling Pathway Postsynaptic Specialization Membrane Synaptic Transmission, GABAergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Chloride Channel Complex CAMP-dependent Protein Kinase Regulator Activity Chloride Channel Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Inner Ear Receptor Cell Development Chloride Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Protein Kinase A Catalytic Subunit Binding GABA-ergic Synapse Chloride Transport Inorganic Anion Transmembrane Transport Regulation Of Biological Quality Innervation CAMP Binding Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Inhibitory Synapse Assembly Negative Regulation Of CAMP/PKA Signal Transduction Monoatomic Ion Channel Activity Neuron Development Cochlea Development Plasma Membrane Raft Membrane Ciliary Base Transmembrane Signaling Receptor Activity Regulation Of CAMP/PKA Signal Transduction Postsynaptic Membrane Transmembrane Transport Circadian Sleep/wake Cycle, REM Sleep Prostaglandin-I Synthase Activity Inorganic Ion Transmembrane Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Regulation Of Cytokinesis
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