CUL2 and TRIP12

Number of citations of the paper that reports this interaction (PubMedID 33567268)
0

Data Source:
BioGRID (pull down)

		CUL2	TRIP12
Description		cullin 2	thyroid hormone receptor interactor 12
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Nuclear Lumen	Nucleus Nucleoplasm Cytosol Nuclear Speck
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination Heterochromatin Boundary Formation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Embryonic Development DNA Repair-dependent Chromatin Remodeling
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Carotid intima media thickness x smoking interaction ( 32117412) Estimated glomerular filtration rate ( 31015462 31152163) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Weight ( 28552196)
Interacting Genes		36 interacting genes: ABI1 ARID1B CAND1 CCND1 CDC34 CHD3 COMMD1 COPS5 CREM DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 FZD8 GJD4 GPS1 HSD17B7P2 KAT2A KHNYN MKNK2 NEDD8 RNF7 SAP130 SENP8 TRIP12 UBC UBE2D1 UBE2D3 UBE2M VHL ZER1 ZNF25 ZYG11B	31 interacting genes: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 CUL2 DSCR9 ERG FBXW7 GBA1 LCOR MTNR1A MTNR1B MYC NAE1 NMI NRIP1 OGT PARP1 PTF1A SMAD4 SMAD9 SOX6 SRPK2 TAF10 THRB UBC UBE2D1 UBE2D2 UBE2L3 UBE4B
Entrez ID		8453	9320
HPRD ID		06786	05144
Ensembl ID		ENSG00000108094	ENSG00000153827
Uniprot IDs		A0A0A0MTN0 A0A140VKB1 A0A8I5KVR3 B7Z1Y1 Q13617	A0A6Q8PGG9 A0A6Q8PHK0 A0A994J4J0 A0A994J569 A0A994J755 H7C1L9 Q14669
PDB IDs		4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 7PLO 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8PQL 8Q7R 8QU8 8R5H 8RWZ 8RX0 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH	9BKR 9BKS
Enriched GO Terms of Interacting Partners?		Protein Neddylation Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Protein Neddylation Protein Modification Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Protein Metabolic Process Cullin Family Protein Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Proteolysis Cul2-RING Ubiquitin Ligase Complex Regulation Of Primary Metabolic Process Ubiquitin Ligase Complex Nucleus Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Binding Regulation Of Macromolecule Metabolic Process Protein Deneddylation Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Protein Modification Process Nucleoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Transcription By RNA Polymerase II Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process NEDD8 Transferase Activity Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Positive Regulation Of Metabolic Process DeNEDDylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Catabolic Process Protein Polyubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity	Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Estrogen Receptor Binding Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Post-translational Protein Modification Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Regulation Of Neuron Apoptotic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Protein-containing Complex Ubiquitin-dependent Protein Catabolic Process Nucleus Negative Regulation Of DNA-templated Transcription DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Melatonin Receptor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process
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