TRIP12 and NAE1

Number of citations of the paper that reports this interaction (PubMedID 18627766)
0

Data Source:
BioGRID (enzymatic study)

		TRIP12	NAE1
Description		thyroid hormone receptor interactor 12	NEDD8 activating enzyme E1 subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Cytoplasm Cytosol Plasma Membrane Membrane Protein-containing Complex Glutamatergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin-like Modifier Activating Enzyme Activity NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination Heterochromatin Boundary Formation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Embryonic Development DNA Repair-dependent Chromatin Remodeling	Apoptotic Process Signal Transduction Mitotic DNA Replication Checkpoint Signaling Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Protein Neddylation Neuron Apoptotic Process Regulation Of Postsynapse Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neddylation
Drugs			ATP
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Estimated glomerular filtration rate ( 31015462 31152163) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Weight ( 28552196)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		31 interacting genes: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 CUL2 DSCR9 ERG FBXW7 GBA1 LCOR MTNR1A MTNR1B MYC NAE1 NMI NRIP1 OGT PARP1 PTF1A SMAD4 SMAD9 SOX6 SRPK2 TAF10 THRB UBC UBE2D1 UBE2D2 UBE2L3 UBE4B	12 interacting genes: ALG8 APP CEBPA GARS1 NEDD8 OGT SREBF2 TP53BP2 TRIP12 UBA3 UBE2F UBQLN4
Entrez ID		9320	8883
HPRD ID		05144	04545
Ensembl ID		ENSG00000153827	ENSG00000159593
Uniprot IDs		A0A6Q8PGG9 A0A6Q8PHK0 A0A994J4J0 A0A994J569 A0A994J755 H7C1L9 Q14669	Q13564
PDB IDs		9BKR 9BKS	1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
Enriched GO Terms of Interacting Partners?		Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Estrogen Receptor Binding Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Post-translational Protein Modification Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Regulation Of Neuron Apoptotic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Protein-containing Complex Ubiquitin-dependent Protein Catabolic Process Nucleus Negative Regulation Of DNA-templated Transcription DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Melatonin Receptor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process	Protein Neddylation Regulation Of Proteolysis NEDD8 Transferase Activity Protein Metabolic Process Regulation Of Amyloid-beta Clearance Regulation Of Protein Catabolic Process Protein-containing Complex Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteolysis Regulation Of Synapse Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytosol Identical Protein Binding Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glycyl-tRNA Aminoacylation Mitochondrial Glycyl-tRNA Aminoacylation Glycine-tRNA Ligase Activity ATP:ATP Adenylyltransferase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity Regulation Of Cell Junction Assembly Regulation Of Carbohydrate Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process Regulation Of Synapse Organization Regulation Of MiRNA Transcription Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Response To Vitamin B2 C/EBP Complex Diadenosine Tetraphosphate Biosynthetic Process C-8 Sterol Isomerase Activity NEDD8 Activating Enzyme Activity
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