BRSK1 and HSD17B7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BRSK1	HSD17B7
Description		BR serine/threonine kinase 1	hydroxysteroid 17-beta dehydrogenase 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Synaptic Vesicle Postsynaptic Density Cell Junction Cytoplasmic Vesicle Cell Projection Synapse Presynaptic Active Zone Cholinergic Synapse Distal Axon	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Gamma-tubulin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Neurotransmitter Secretion Nervous System Development Axonogenesis Associative Learning Response To UV Response To Ionizing Radiation Regulation Of Synaptic Vesicle Priming Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Central Nervous System Neuron Differentiation Establishment Of Cell Polarity Neuron Differentiation Regulation Of Synaptic Plasticity Neuron Projection Morphogenesis Regulation Of Axonogenesis Centrosome Duplication Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Clustering	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Estrogen Biosynthetic Process Nervous System Development Brain Development Androgen Metabolic Process Cell Differentiation Embryonic Organ Development Embryonic Skeletal System Development
Pathways			Cholesterol biosynthesis Cholesterol biosynthesis via lathosterol
Drugs			NADH
Diseases
GWAS		Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 26414677)	Dupuytren's disease ( 28886342)
Interacting Genes		9 interacting genes: BRCA1 CDC25B CDC25C DNAAF3 HSD17B7 HSPA1A MAPT PAK1 WEE1	7 interacting genes: BRSK1 CA1 DTYMK GORAB GPAT4 PBRM1 VKORC1
Entrez ID		84446	51478
HPRD ID		12533	05996
Ensembl ID		ENSG00000160469	ENSG00000132196
Uniprot IDs		Q8TDC3	P56937
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of Microtubule Polymerization Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Microtubule Nucleation Positive Regulation Of Protein Polymerization Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Growth Positive Regulation Of Mitotic Cell Cycle Regulation Of Microtubule Nucleation Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Protein Kinase Binding Cell Cycle Phase Transition Positive Regulation Of Meiotic Cell Cycle Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Cell Growth Positive Regulation Of Supramolecular Fiber Organization Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Growth Regulation Of Organelle Organization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Growth Positive Regulation Of Axon Extension Positive Regulation Of Cell Cycle Process Cellular Response To Heat Tubulin Binding Microtubule-based Process Regulation Of Meiotic Cell Cycle Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Positive Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Organelle Organization	DTMP Kinase Activity DUDP Biosynthetic Process DTDP Biosynthetic Process Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Cyanamide Hydratase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Glycerol-3-phosphate O-acyltransferase Activity Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Distal Axon Arylesterase Activity Thymidine Biosynthetic Process DTTP Biosynthetic Process Synaptic Vesicle Cycle Hydro-lyase Activity Thymidine Metabolic Process Pyrimidine Deoxyribonucleotide Biosynthetic Process Regulation Of Synaptic Vesicle Clustering Glandular Epithelial Cell Maturation Response To Fructose Quinone Binding Regulation Of Synaptic Vesicle Priming Cholinergic Synapse Lysophosphatidic Acid Acyltransferase Activity CDP-diacylglycerol Biosynthetic Process Columnar/cuboidal Epithelial Cell Maturation Carbonate Dehydratase Activity Pyrimidine Nucleoside Metabolic Process 2'-deoxyribonucleotide Biosynthetic Process Nucleoside Diphosphate Kinase Activity Deoxyribonucleotide Biosynthetic Process Nucleoside Diphosphate Biosynthetic Process RSC-type Complex Peptidyl-glutamic Acid Modification Regulation Of Body Fluid Levels Vitamin K Metabolic Process CDP-diacylglycerol Metabolic Process 1-acylglycerol-3-phosphate O-acyltransferase Activity Triglyceride Biosynthetic Process
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