DOT1L and UBE3C

Number of citations of the paper that reports this interaction (PubMedID 34551297)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		DOT1L	UBE3C
Description		DOT1 like histone lysine methyltransferase	ubiquitin protein ligase E3C
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Protein-containing Complex	Proteasome Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity Protein Binding Methyltransferase Activity Transferase Activity Histone H3K79 Methyltransferase Activity Histone Methyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3 Methyltransferase Activity Histone H3K79 Trimethyltransferase Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair Chromatin Organization Gene Expression Heterochromatin Formation Subtelomeric Heterochromatin Formation Telomere Organization Methylation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Cycle Regulation Of Transcription Regulatory Region DNA Binding	Autophagosome Assembly Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Phosphatidylinositol Phosphate Biosynthetic Process Protein K48-linked Ubiquitination
Pathways		PKMTs methylate histone lysines	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 23563607 25282103 18391950 28552196) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172 25673412) Hip minimal joint space width ( 27701424) Myocardial infarction ( 24916648) Osteoarthritis ( 22566624) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878 30578418 30487518 29403010 26390057 27618448) Red blood cell count ( 29403010) Systemic lupus erythematosus ( 33493351) Systolic blood pressure ( 30487518 27618448) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Body mass index ( 25673413) Language impairment in frontotemporal lobe dementia ( 29724592) Quantitative traits ( 19197348) Response to citalopram treatment ( 19846067) Type 2 diabetes ( 30054458)
Interacting Genes		6 interacting genes: H3-4 MAPK11 MLLT10 MYCN STAT1 UBE3C	17 interacting genes: APP BIRC6 CAND2 CCNB1 DOT1L GOLGA2 GRSF1 MTA2 PIK3C3 PSMC5 PSMD2 TLK1 TP73 UBE2D1 UBE2D2 UBE2D3 UBE2L3
Entrez ID		84444	9690
HPRD ID		10455	15604
Ensembl ID		ENSG00000104885	ENSG00000009335
Uniprot IDs		A0A8I5QL06 Q8TEK3	Q15386
PDB IDs		1NW3 2MV7 3QOW 3QOX 3SR4 3SX0 3UWP 4EK9 4EKG 4EKI 4EQZ 4ER0 4ER3 4ER5 4ER6 4ER7 4HRA 4WVL 5DRT 5DRY 5DSX 5DT2 5DTM 5DTQ 5DTR 5JUW 5MVS 5MW3 5MW4 6IN3 6J99 6JM9 6JMA 6JN2 6NJ9 6NN6 6NOG 6NQA 6O96 6TE6 6TEL 6TEN 7BWD 7EDP 7S7E 7S7F 7XCR 7XCT	6K2C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Erythrocyte Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Autosome Genomic Imprinting Regulation Of Cell Development DNA Binding Cell Population Proliferation Regulation Of Epithelial Cell Differentiation Regulation Of Cell Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation NLRP1 Inflammasome Complex Assembly Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Histone Binding Interleukin-7-mediated Signaling Pathway ISGF3 Complex Negative Regulation By Virus Of Viral Protein Levels In Host Cell Interleukin-27-mediated Signaling Pathway Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Mesenchymal Cell Differentiation Involved In Kidney Development Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Negative Regulation Of Developmental Process Nucleoplasm Regulation Of Inner Ear Auditory Receptor Cell Differentiation Cell Proliferation Involved In Kidney Development Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Nephron Tubule Epithelial Cell Differentiation Protein K29-linked Ubiquitination Regulation Of Developmental Process Negative Regulation Of Astrocyte Differentiation Cellular Response To UV-B Type II Interferon-mediated Signaling Pathway Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process MAP Kinase Activity Positive Regulation Of Gene Expression	Ubiquitin Conjugating Enzyme Activity Macromolecule Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Protein Modification Process Proteolysis Proteasome Regulatory Particle, Base Subcomplex Proteasome Regulatory Particle Positive Regulation Of Protein Metabolic Process Protein Tetramerization Post-translational Protein Modification Transferase Activity Proteasome Accessory Complex Protein Polyubiquitination Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus ATP Binding Catabolic Process TBP-class Protein Binding Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Protein Modification Process Spindle Pole Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein-containing Complex DNA-binding Transcription Factor Binding Protein K11-linked Ubiquitination
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